Carleton University
Theoretical Considerations in the Estimation of the Signal-to-Noise Crossover Dose
Abstract
dc:description.abstractA goal of health risk assessment is the determination of the reference dose. The estimation of the point of departure plays an important role in the derivation of the reference dose. The method of benchmark dose has been widely employed in the determination of the point of departure. However, due to some practical constraints, the method sometimes faces difficulty in determining an appropriate increase in risk that meets the definition of the reference dose. As an alternative, the method of the signal-to-noise crossover dose (SNCD) was introduced in 2011. One of the main objectives here is to develop an optimal design for the SNCR: an additional risk associated with the SNCD. The feasibility of the optimal design is also investigated under different dose-response relationships.
Degree
thesis:*- Name thesis:degree_name
- Master of Science (M.Sc.)
- Level thesis:degree_level
- Master's
- Discipline thesis:degree_discipline
- Probability and Statistics
- Grantor dc:publisher
- Carleton University
- Year dc:date.issued
- 2014
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Hagiwara, Shintaro
Rights
dc:rights- Statement dc:rights
-
- Copyright © 2014 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:carleton.scholaris.ca:20.500.14718/38227