{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/9521"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/9521","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Immunology and virology of HIV-1 infection in Cameroon","abstract":"This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be crucial for dissecting the earliest evolutionary steps in the emergence of HIV-1 group M. In addition, the central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE peptides did not increase the breadth of T cell recognition in Abstract Page xvi this divergent population when compared to consensus M peptides. This underlies the need to include more mosaic peptides representing the variety of viruses that circulate in the region.","abstract_html":"This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be crucial for dissecting the earliest evolutionary steps in the emergence of HIV-1 group M. In addition, the central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE peptides did not increase the breadth of T cell recognition in Abstract Page xvi this divergent population when compared to consensus M peptides. This underlies the need to include more mosaic peptides representing the variety of viruses that circulate in the region.","abstract_has_math":false,"creators":["Tongo Passo, Aime Marcel Simon"],"institution":"Division of Virology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Burgers, Wendy","Martin, Darren"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-22T22:23:31Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/9521","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Burgers, Wendy","Martin, Darren"]},{"key":"dc:creator","label":"Author","values":["Tongo Passo, Aime Marcel Simon"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-11-11T06:49:55Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-11-11T06:49:55Z"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Virology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/9521"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be crucial for dissecting the earliest evolutionary steps in the emergence of HIV-1 group M. In addition, the central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE peptides did not increase the breadth of T cell recognition in Abstract Page xvi this divergent population when compared to consensus M peptides. This underlies the need to include more mosaic peptides representing the variety of viruses that circulate in the region."]},{"key":"dc:title","label":"Title","values":["Immunology and virology of HIV-1 infection in Cameroon"]}]}],"canonical_facts":{"dc:contributor.advisor":["Burgers, Wendy","Martin, Darren"],"dc:creator":["Tongo Passo, Aime Marcel Simon"],"dc:date.accessioned":["2014-11-11T06:49:55Z"],"dc:date.available":["2014-11-11T06:49:55Z"],"dc:date.issued":["2014"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be crucial for dissecting the earliest evolutionary steps in the emergence of HIV-1 group M. In addition, the central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE peptides did not increase the breadth of T cell recognition in Abstract Page xvi this divergent population when compared to consensus M peptides. This underlies the need to include more mosaic peptides representing the variety of viruses that circulate in the region."],"dc:identifier.uri":["http://hdl.handle.net/11427/9521"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Virology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Immunology and virology of HIV-1 infection in Cameroon"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:31Z"}