{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/9281"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/9281","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents","abstract":"The first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the same synthetic methodology. The synthesis involved a radical addition and a chemoselective oxidation as key steps. Characterisation was carried out by [1]H NMR, [13]C NMR, IR and HRMS spectroscopies.","abstract_html":"The first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the same synthetic methodology. The synthesis involved a radical addition and a chemoselective oxidation as key steps. Characterisation was carried out by [1]H NMR, [13]C NMR, IR and HRMS spectroscopies.","abstract_has_math":false,"creators":["Qwebani, Tozama"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Hunter, Roger","Caira, Mino R"],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009","date_published":"2009","updated_at":"2026-07-22T22:23:23Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/9281","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Hunter, Roger","Caira, Mino R"]},{"key":"dc:creator","label":"Author","values":["Qwebani, Tozama"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-11-05T17:41:59Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-11-05T17:41:59Z"]},{"key":"dc:date.issued","label":"Date","values":["2009"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/9281"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 107-111)."]},{"key":"dc:description.abstract","label":"Abstract","values":["The first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the same synthetic methodology. The synthesis involved a radical addition and a chemoselective oxidation as key steps. Characterisation was carried out by [1]H NMR, [13]C NMR, IR and HRMS spectroscopies."]},{"key":"dc:title","label":"Title","values":["Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents"]}]}],"canonical_facts":{"dc:contributor.advisor":["Hunter, Roger","Caira, Mino R"],"dc:creator":["Qwebani, Tozama"],"dc:date.accessioned":["2014-11-05T17:41:59Z"],"dc:date.available":["2014-11-05T17:41:59Z"],"dc:date.issued":["2009"],"dc:description":["Includes bibliographical references (leaves 107-111)."],"dc:description.abstract":["The first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the same synthetic methodology. The synthesis involved a radical addition and a chemoselective oxidation as key steps. Characterisation was carried out by [1]H NMR, [13]C NMR, IR and HRMS spectroscopies."],"dc:identifier.uri":["http://hdl.handle.net/11427/9281"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:23Z"}