Development of new bioorganometallic metallodendrimers as in vitro anticancer agents

The clinical success of cisplatin and its derivatives for the treatment of different cancers has had a profound effect on the use of metal-containing agents in medicine. Despite the successes, the drawbacks of platinum-based therapy, such as drug resistance, toxicity and the emergence of unwanted side effects, have bred a need for effective and novel anticancer agents. Hence, the design and study of bioorganometallic complexes as potential therapeutic agents may eventually lead to the identification of new drug candidates. The purpose of this study was to synthesize and characterize a series of polynuclear transition-metal-containing complexes based on a (poly)propyleneimine dendritic scaffold, and investigate the in vitro antiproliferative activity of these complexes.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2014

Author dc:creator

• Govender, Preshendren

Advisor dc:contributor.advisor

• Smith, Gregory S

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/8720

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/8720