{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/6670"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/6670","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Proteoglycan genes and anterior cruciate ligament injury susceptibility","abstract":"Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured controls. Genes encoding proteoglycans are therefore plausible candidates to be investigated for an association with ACL injury susceptibility.","abstract_html":"Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured controls. Genes encoding proteoglycans are therefore plausible candidates to be investigated for an association with ACL injury susceptibility.","abstract_has_math":false,"creators":["Mannion, Sasha"],"institution":"Division of Human Genetics","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["September, Alison","Collins, Malcolm"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-22T22:23:31Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/6670","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["September, Alison","Collins, Malcolm"]},{"key":"dc:creator","label":"Author","values":["Mannion, Sasha"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-08-22T10:37:01Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-08-22T10:37:01Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Human Genetics"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/6670"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured controls. Genes encoding proteoglycans are therefore plausible candidates to be investigated for an association with ACL injury susceptibility."]},{"key":"dc:title","label":"Title","values":["Proteoglycan genes and anterior cruciate ligament injury susceptibility"]}]}],"canonical_facts":{"dc:contributor.advisor":["September, Alison","Collins, Malcolm"],"dc:creator":["Mannion, Sasha"],"dc:date.accessioned":["2014-08-22T10:37:01Z"],"dc:date.available":["2014-08-22T10:37:01Z"],"dc:date.issued":["2013"],"dc:description":["Includes abstract.","Includes bibliographical references."],"dc:description.abstract":["Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured controls. Genes encoding proteoglycans are therefore plausible candidates to be investigated for an association with ACL injury susceptibility."],"dc:identifier.uri":["http://hdl.handle.net/11427/6670"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Human Genetics"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Proteoglycan genes and anterior cruciate ligament injury susceptibility"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:31Z"}