Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation.

Trema orientalis, a widely distributed evergreen tree with various medicinal properties including the treatment of malaria, was investigated as a potential source of new antimalarial lead compounds. Organic extracts of the young growing twigs of T. orientalis were reproducibly shown to be active against the chloroquine-sensitive (D10) and chloroquine resistant (K1) strains of Plasmodium falciparum. The 8-O-4' oxyneolignans, dadahols A and B, were identified as the major active compounds using two bioassay-guided fractionation approaches. The new accelerated “HPLC biogram” methodology allowed for early recognition of the active compounds in the complex plant extract, requiring considerably less time and material compared to the classical reiterative approach.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2011

Author dc:creator

• Pillay, Pamisha

Advisors dc:contributor.advisor

• Chibale, Kelly
• Maharaj, Vinesh

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6357

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6357