Thermodynamic properties of diamino-diamide ligand as potential anti-inflammatory agent

It has been found that low molecular mass copper(II) complexes are effective in the treatment of rheumatoid) arthritis (RA). Increasing the amount of copper associated with low molecular mass ligands in plasma helps to alleviate the symptoms of rheumatoid arthritis. Low molecular weight ligand, 3,5-bis[(aminoethyl)ethanediamideJ-4-oxahexacyclododecane (PCUA) was investigated using glass electrode potentiometry, UV/Visible spectroscopy, nuclear magnetic resonance spectroscopy, speciation modelling as well as blood plasma modelling.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2003

Author dc:creator

• Odisitse, Sebusi

Advisor dc:contributor.advisor

• Jackson, Graham Ellis

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6355

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6355