Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques

The need to come up with new and novel antibiotics that utilize unique mechanisms, to which bacteria cannot generate resistance, was the main motivation of this study. Tyrocidine peptides are non-selective antibiotics that have such properties. However, very limited information is available about their mechanism of action. The aim of this study was to determine the mechanism of action of tyrocidine peptides, tyrocidine A, tyrocidine B and tyrocidine C.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2012

Author dc:creator

• Munyuki, Gadzikano

Advisors dc:contributor.advisor

• Jackson, Graham Ellis
• Venter, Gerhard

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6347

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6347