Synthesis of N-alkyl-and N,N-dialkyl-N'-acyl- and N'-aroythioureas, and aspects of their co-ordination chemistry with Pt(II)and Pd(II)

The synthesis of simple, and also bipodal N-substituted N'-acyl- and N'-aroylthiourea ligands has been investigated, along with aspects of their co-ordination chemistry to Pt(II) and Pd(II). The ligands are commonly produced by reacting a secondary or primary amine with an acyl or aroyl isothiocyanate. This synthesis requires nucleophilic addition of the amine to the thiocarbonyl carbon of the acyl or aroyl isothocyanate. However, a competitive side-reaction frequently occurs because the amine nucleophile can attack the carbonyl carbon of the isothiocyanate reagent instead. This leads to substitution of the isothiocyanate moiety and the formation of an N-substituted amide.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2000

Author dc:creator

• Miller, Jörn Derrick Schuster

Advisor dc:contributor.advisor

• Koch, Klaus

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6336

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6336