Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery

Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2003

Author dc:creator

• Mabizela, Nontobeko

Advisor dc:contributor.advisor

• Chibale, Kelly

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6325

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6325