Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria

Tuberculosis (TB) is a contagious respiratory disease caused by Mycobacterium tuberculosis. Due to lack of an efficient and short-term treatment of TB, the bacterium has become resistant to the first line antibiotics and the disease has ranked next to HIV/AIDS. A low molecular weight thiol called myctothiol protects the bacteria from many foreign stress factors and secures its survival. Studies have shown the mycothiol-deficient bacteria are hypersensitive to external stresses and hence inhibition of the biosynthesis of mycothiol could be a drug lead against TB.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2006

Author dc:creator

• Kinfe, Henok Hadgu

Advisor dc:contributor.advisor

• Gammon, David W

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6318

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6318