Rationalising the effect of guanine-based Ricin inhibitors using computer simulations

for humans.This has lead to its use as a biological weapon and a therapeutic agent. the reaction mechanism of ricin is not known and so rational design is limited, resulting in no effective inhibitor being found for this enzyme. An important step towards understanding the reaction mechanism and the design of effective inhibitors is the complete understanding of the binding pocket and the mode/nature of binding ligands to the protein. In this thesis computational methods were used to rationalise the effect of selected ricin inhibitors.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2008

Author dc:creator

• Jayakody, Ranga S

Advisor dc:contributor.advisor

• Naidoo, Kevin J

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6315

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6315