Investigations of the solution properties of both unmodified and modified cyclodextrins

The major part of this focuses on investigating the anomalous solubility of β-cyclodextrin using time correlation functions as the main tool for analysis. The primary focus is on the conformational metrics which govern the internal motions of the three main, unmodified cyclodextrins (namely a, β and y). The conformational space and dynamics of the interglycosidic dihedral angles, individual glucose tilting and verticallibrations of each glucose unit is investigated. Also the hydrogen bonding across the glycosidic linkage is examined. We then investigate the solution properties of cyclodextrin solutions using both ultrasonic interferometry and molecular dynamics.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2008

Author dc:creator

• Gamieldien, Mogamat Riedaa

Advisor dc:contributor.advisor

• Naidoo, Kevin J

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6306

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6306