Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene

This study describes the preparation and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD heptakis(2,6-di-O-methyl )-β-CD (DIMEB) and heptakls(2, 3, 6-tri-O-methyl )-β-CD (TRIMEB) to yield inclusion compounds α-CD·(E)-ajoene (1), α-CD·(Z)ajoene (2), β-CD·(E)-ajoene (3), β-CD·(Z)-ajoene (4), y-CD·(E)-ajoene (5), y-CD·(Z)-ajoene (6), DIMEB·(E)-ajoene (7), DIMEB·(Z)-ajoene (6), TRIMEB·(E)-ajoene·05H20 (9) and TRIMEB·(Z)-ajoene (10).

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2004

Author dc:creator

• Smith, Vincent Joseph

Advisors dc:contributor.advisor

• Caira, Mino R
• Hunter, Roger
• Bourne, Susan

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6293

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6293