{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/6280"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/6280","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline","abstract":"A series of twelve 4-amino-7-chloroquinolines containing (N, N-dibenzylmethylamine) dibemethin side chains attached to the amino group of the quinoline were synthesized by reaction of aminomethyl dibemethins with 4,7-dichloroquinoline to give “dibemethinoquines”. The attachment between the quinoline ring and the side chain was varied from ortho, to meta to para. The aminomethyl dibemethin side chains were synthesized using the Staudinger reduction of azides or the reductive amination via oxime of an aldehyde. Derivatives in which the para substituent on the terminal phenyl ring were altered from the parent compound (X = H) by replacement with Cl, OCH₃ orNMe₂ group were also synthesized. The choice of substituents was based on the Topliss scheme.","abstract_html":"A series of twelve 4-amino-7-chloroquinolines containing (N, N-dibenzylmethylamine) dibemethin side chains attached to the amino group of the quinoline were synthesized by reaction of aminomethyl dibemethins with 4,7-dichloroquinoline to give “dibemethinoquines”. The attachment between the quinoline ring and the side chain was varied from ortho, to meta to para. The aminomethyl dibemethin side chains were synthesized using the Staudinger reduction of azides or the reductive amination via oxime of an aldehyde. Derivatives in which the para substituent on the terminal phenyl ring were altered from the parent compound (X = H) by replacement with Cl, OCH₃ orNMe₂ group were also synthesized. The choice of substituents was based on the Topliss scheme.","abstract_has_math":false,"creators":["Zishiri, Vincent Kudakwashe"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Egan, Timothy J","Hunter, Roger"],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008","date_published":"2008","updated_at":"2026-07-22T22:23:19Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/6280","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Egan, Timothy J","Hunter, Roger"]},{"key":"dc:creator","label":"Author","values":["Zishiri, Vincent Kudakwashe"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-08-13T14:25:24Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-08-13T14:25:24Z"]},{"key":"dc:date.issued","label":"Date","values":["2008"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/6280"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references (leaves 138-154)."]},{"key":"dc:description.abstract","label":"Abstract","values":["A series of twelve 4-amino-7-chloroquinolines containing (N, N-dibenzylmethylamine) dibemethin side chains attached to the amino group of the quinoline were synthesized by reaction of aminomethyl dibemethins with 4,7-dichloroquinoline to give “dibemethinoquines”. The attachment between the quinoline ring and the side chain was varied from ortho, to meta to para. The aminomethyl dibemethin side chains were synthesized using the Staudinger reduction of azides or the reductive amination via oxime of an aldehyde. Derivatives in which the para substituent on the terminal phenyl ring were altered from the parent compound (X = H) by replacement with Cl, OCH₃ orNMe₂ group were also synthesized. The choice of substituents was based on the Topliss scheme."]},{"key":"dc:title","label":"Title","values":["Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline"]}]}],"canonical_facts":{"dc:contributor.advisor":["Egan, Timothy J","Hunter, Roger"],"dc:creator":["Zishiri, Vincent Kudakwashe"],"dc:date.accessioned":["2014-08-13T14:25:24Z"],"dc:date.available":["2014-08-13T14:25:24Z"],"dc:date.issued":["2008"],"dc:description":["Includes abstract.","Includes bibliographical references (leaves 138-154)."],"dc:description.abstract":["A series of twelve 4-amino-7-chloroquinolines containing (N, N-dibenzylmethylamine) dibemethin side chains attached to the amino group of the quinoline were synthesized by reaction of aminomethyl dibemethins with 4,7-dichloroquinoline to give “dibemethinoquines”. The attachment between the quinoline ring and the side chain was varied from ortho, to meta to para. The aminomethyl dibemethin side chains were synthesized using the Staudinger reduction of azides or the reductive amination via oxime of an aldehyde. Derivatives in which the para substituent on the terminal phenyl ring were altered from the parent compound (X = H) by replacement with Cl, OCH₃ orNMe₂ group were also synthesized. The choice of substituents was based on the Topliss scheme."],"dc:identifier.uri":["http://hdl.handle.net/11427/6280"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:19Z"}