Safety of long-term isoniazid preventive therapy in children with HIV

Tuberculosis (TB) and HIV co-infection is association with significant morbidity and mortality, especially in young children. Prevention of tuberculosis in children with HIV is a global health priority and is best achieved through a combination of antiretroviral therapy (ART) and isoniazid preventive therapy (IPT). Current WHO guidelines recommend 6 months of IPT for all HIV-infected children older than 1 year without TB disease; up to 3 years is recommended in high TB prevalence areas. Although both ART and IPT can cause liver injury, data on the safety of IPT in HIV-infected children accessing ART is limited, and no published data exist on the hepatotoxicity risk of prolonged IPT. This thesis aims to address these knowledge gaps.

Grantor dc:publisher.institution

Department of Public Health and Family Medicine

Year dc:date.issued

2014

Author dc:creator

• Le Roux, Stanzi Maria

Advisors dc:contributor.advisor

• Myer, Landon
• Zar, Heather

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6023

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6023