A detailed investigation of microbial cell disruption by hydrodynamic cavitation for selective product release

Hydrodynamic cavitation is a novel method for microbial cell disruption, mediated by intense pressure fluctuations caused by cavity oscillation and collapse. Selective release of intracellular microbial products is desirable to reduce the cost involved in their downstream processing. A study of the process variables that affect microbial cell disruption by hydrodynamic cavitation is presented in order to ascertain the conditions required for a selective release. Two model systems were considered (yeast and E. coil). Enzymes from different locations of the cell were studied and the release compared with other methods of disruption.

Grantor dc:publisher.institution

Centre for Bioprocess Engineering Research

Year dc:date.issued

2004

Author dc:creator

• Bangaru, Balasundaram

Advisor dc:contributor.advisor

• Harrison, STL

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/5345

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/5345