{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/4284"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/4284","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The crystal structure of a mutant nitrile hydratase","abstract":"Nitrile hydratases can be used as industrial biocatalysts. They catalyze the conversion of nitriles to their corresponding amides. These industrial biocatalysts have recently gained attention due to the economic production of industrial commodities such as acrylamide and nicotinamide (Thomas et at., 2002). Nitrile hydratases (NHases) are metalloenzymes made up of α and β subunits, and exist mostly as heterotetramers (αβ)₂. They are categorized into Co-containing and Fe-containing types depending on their co-factor requirements.","abstract_html":"Nitrile hydratases can be used as industrial biocatalysts. They catalyze the conversion of nitriles to their corresponding amides. These industrial biocatalysts have recently gained attention due to the economic production of industrial commodities such as acrylamide and nicotinamide (Thomas et at., 2002). Nitrile hydratases (NHases) are metalloenzymes made up of α and β subunits, and exist mostly as heterotetramers (αβ)₂. They are categorized into Co-containing and Fe-containing types depending on their co-factor requirements.","abstract_has_math":false,"creators":["Kwofie, Samuel Kojo"],"institution":"Department of Molecular and Cell Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Cowan, DA"],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-22T22:22:52Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/4284","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Cowan, DA"]},{"key":"dc:creator","label":"Author","values":["Kwofie, Samuel Kojo"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-30T17:38:47Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-30T17:38:47Z"]},{"key":"dc:date.issued","label":"Date","values":["2006"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Molecular and Cell Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/4284"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["Nitrile hydratases can be used as industrial biocatalysts. They catalyze the conversion of nitriles to their corresponding amides. These industrial biocatalysts have recently gained attention due to the economic production of industrial commodities such as acrylamide and nicotinamide (Thomas et at., 2002). Nitrile hydratases (NHases) are metalloenzymes made up of α and β subunits, and exist mostly as heterotetramers (αβ)₂. They are categorized into Co-containing and Fe-containing types depending on their co-factor requirements."]},{"key":"dc:title","label":"Title","values":["The crystal structure of a mutant nitrile hydratase"]}]}],"canonical_facts":{"dc:contributor.advisor":["Cowan, DA"],"dc:creator":["Kwofie, Samuel Kojo"],"dc:date.accessioned":["2014-07-30T17:38:47Z"],"dc:date.available":["2014-07-30T17:38:47Z"],"dc:date.issued":["2006"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["Nitrile hydratases can be used as industrial biocatalysts. They catalyze the conversion of nitriles to their corresponding amides. These industrial biocatalysts have recently gained attention due to the economic production of industrial commodities such as acrylamide and nicotinamide (Thomas et at., 2002). Nitrile hydratases (NHases) are metalloenzymes made up of α and β subunits, and exist mostly as heterotetramers (αβ)₂. They are categorized into Co-containing and Fe-containing types depending on their co-factor requirements."],"dc:identifier.uri":["http://hdl.handle.net/11427/4284"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Molecular and Cell Biology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The crystal structure of a mutant nitrile hydratase"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:22:52Z"}