Structure and metabolism of bovine aortic proteoglycans

Although a number of studies of arterial glycosaminoglycans have been carried out, there is comparatively little information available regarding the native state in which these glycosaminoglycans occur, namely covalently bound to protein to form proteoglycans. There are numerous factors that make arterial proteoglycans difficult to study, such as their relatively low concentration in the tissue a s compared to cartilaginous tissue, and their association with the fibrous elements of the matrix which make quantitative extraction difficult. In recent years reports of characterizations of arterial proteoglycans have appeared in the literature but they differ markedly in several respects. In order to minimize such variables, proteoglycans isolated from pure medial tissue of bovine aortas from different age groups have been studied. Isolation of these proteoglycans was carried out essentially as described for their counterparts from cartilage. Furthermore, proteoglycans have been isolated from a cultured clonal line of foetal bovine aortic medial smooth muscle cells and comparison s made between the two sources of material in terms of their proteoglycan monomer size and glycosaminoglycan composition.

Grantor dc:publisher.institution

Division of Biomedical Engineering

Year dc:date.issued

1983

Author dc:creator

• Murray, Eileen

Advisor dc:contributor.advisor

• Scott-Burden, Timothy

• arterial glycosaminoglycans
• proteoglycans

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/11427/42831

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/42831