The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
type: CreativeWork
description: Despite the burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and 74.2% of patients had advanced stage HL. Patient prognosis was scored using the HL International Prognostic Score (IPS-7) and HL IPS-3. Seventy (24.6%) patients were transfused with a median of 2(IQR 1-5) units per patient. Compared to HIV-negative patients, more HIV-positive patients were transfused (14.1% vs 40.4%, P<0.001) and received more units, median 2(IQR 1-3) vs. 3(IQR 2-5), P=0.035. HL IPS-7 (OR 2.1, P<0.001) and HL IPS-3 (OR 2.6, P<0.001) were independently associated with transfusion. HL IPS-7, HL IPS-3 and HIV positivity remained associated with transfusion after adjusting for covariates. For patients with newly diagnosed HL, HL IPS-7, HL IPS-3 and HIV status predicted transfusion.
abstract: Despite the burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and 74.2% of patients had advanced stage HL. Patient prognosis was scored using the HL International Prognostic Score (IPS-7) and HL IPS-3. Seventy (24.6%) patients were transfused with a median of 2(IQR 1-5) units per patient. Compared to HIV-negative patients, more HIV-positive patients were transfused (14.1% vs 40.4%, P<0.001) and received more units, median 2(IQR 1-3) vs. 3(IQR 2-5), P=0.035. HL IPS-7 (OR 2.1, P<0.001) and HL IPS-3 (OR 2.6, P<0.001) were independently associated with transfusion. HL IPS-7, HL IPS-3 and HIV positivity remained associated with transfusion after adjusting for covariates. For patients with newly diagnosed HL, HL IPS-7, HL IPS-3 and HIV status predicted transfusion.
author: Simba, Kudakwashe
language: en
keywords: HIV, Hodgkin lymphoma
date published: 2025
date modified: 2026-07-22T22:23:34Z
provider: University of Cape Town
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Department of Medicine

PropertyValue
property ID: Handle
value: http://hdl.handle.net/11427/42775