{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/42646"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/42646","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa","abstract":"Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life of patients. The objective of this study was to assess the long-term effects of MIS-C on the quality of life of children. Methods: This study was a prospective, case control, cohort study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the school functioning, social, emotional, and physical domains of the two groups. Results: All participants with previous MIS-C made a full recovery with normal physical examination after a median of 705 days after acute MIS-C. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p<0.001). There was a deficit in the psychosocial domain (which combines emotional, social and educational scores) in 12.5% children with previous MIS-C compared to 40% children with JIA (p=0.035) Conclusions: In 24 children with previous MIS-C, after approximately 2 years, no medical complications were reported. A small proportion felt a prolonged effect on their quality of life even after making a full recovery, which was less severe than in children with JIA. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care.","abstract_html":"Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life of patients. The objective of this study was to assess the long-term effects of MIS-C on the quality of life of children. Methods: This study was a prospective, case control, cohort study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the school functioning, social, emotional, and physical domains of the two groups. Results: All participants with previous MIS-C made a full recovery with normal physical examination after a median of 705 days after acute MIS-C. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p&lt;0.001). There was a deficit in the psychosocial domain (which combines emotional, social and educational scores) in 12.5% children with previous MIS-C compared to 40% children with JIA (p=0.035) Conclusions: In 24 children with previous MIS-C, after approximately 2 years, no medical complications were reported. A small proportion felt a prolonged effect on their quality of life even after making a full recovery, which was less severe than in children with JIA. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care.","abstract_has_math":false,"creators":["Phoya, Frank"],"institution":"Department of Paediatrics and Child Health","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Webb, Kate","Scott, Christiaan"],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025","date_published":"2025","updated_at":"2026-07-22T22:23:23Z","subjects":["Multisystem inflammatory syndrome","Children","Cape Town"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/42646","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Webb, Kate","Scott, Christiaan"]},{"key":"dc:creator","label":"Author","values":["Phoya, Frank"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2026-01-22T07:17:14Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2026-01-22T07:17:14Z"]},{"key":"dc:date.issued","label":"Date","values":["2025"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Paediatrics and Child Health"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Multisystem inflammatory syndrome","Children","Cape Town"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/42646"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life of patients. The objective of this study was to assess the long-term effects of MIS-C on the quality of life of children. Methods: This study was a prospective, case control, cohort study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the school functioning, social, emotional, and physical domains of the two groups. Results: All participants with previous MIS-C made a full recovery with normal physical examination after a median of 705 days after acute MIS-C. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p<0.001). There was a deficit in the psychosocial domain (which combines emotional, social and educational scores) in 12.5% children with previous MIS-C compared to 40% children with JIA (p=0.035) Conclusions: In 24 children with previous MIS-C, after approximately 2 years, no medical complications were reported. A small proportion felt a prolonged effect on their quality of life even after making a full recovery, which was less severe than in children with JIA. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care."]},{"key":"dc:title","label":"Title","values":["Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa"]}]}],"canonical_facts":{"dc:contributor.advisor":["Webb, Kate","Scott, Christiaan"],"dc:creator":["Phoya, Frank"],"dc:date.accessioned":["2026-01-22T07:17:14Z"],"dc:date.available":["2026-01-22T07:17:14Z"],"dc:date.issued":["2025"],"dc:description.abstract":["Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life of patients. The objective of this study was to assess the long-term effects of MIS-C on the quality of life of children. Methods: This study was a prospective, case control, cohort study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the school functioning, social, emotional, and physical domains of the two groups. Results: All participants with previous MIS-C made a full recovery with normal physical examination after a median of 705 days after acute MIS-C. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p<0.001). There was a deficit in the psychosocial domain (which combines emotional, social and educational scores) in 12.5% children with previous MIS-C compared to 40% children with JIA (p=0.035) Conclusions: In 24 children with previous MIS-C, after approximately 2 years, no medical complications were reported. A small proportion felt a prolonged effect on their quality of life even after making a full recovery, which was less severe than in children with JIA. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care."],"dc:identifier.uri":["http://hdl.handle.net/11427/42646"],"dc:language.iso":["en"],"dc:publisher.department":["Department of Paediatrics and Child Health"],"dc:publisher.institution":["University of Cape Town"],"dc:subject":["Multisystem inflammatory syndrome","Children","Cape Town"],"dc:title":["Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Masters"]},"updated_at":"2026-07-22T22:23:23Z"}