Compaction of chromatin in Saccharomyces cerevisiae

This study investigated the link between the association of the yeast linker histone homologue, Hholp, and the compaction of the yeast genome during stationary phase. The relative gene content of condensed chromatin, fractionated and isolated by sucrose gradient ultracentrifugation from stationary and exponential phase cultures was compared using genome-wide technologies. This study showed that condensed chromatin of stationary phase culture contained an enriched density of genes on all the chromosomes, indicating global compaction of the yeast genome during stationary phase.

Grantor dc:publisher.institution

Department of Molecular and Cell Biology

Year dc:date.issued

2006

Author dc:creator

• Chang, Cheng-Fu

Advisor dc:contributor.advisor

• Patterton, Hugh

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/4247

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/4247