{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/42065"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/42065","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"MPhil in pulmonary haemorrhage in children in Cape Town","abstract":"Introduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopathological features of DAH and its management on the outcomes of children with this diagnosis. Methods: A descriptive study was conducted on children attending a tertiary centre pulmonology clinic from the period 2000-2022. A review of the clinical data, investigations and lung biopsy results was done and outcomes were reported. Results: Sixteen children were included in the study. The median age at presentation was 1.79 years (IQR 0.48-3.15). At presentation, the median haemoglobulin (Hb)was 5.4 (IQR 3.6-85). Five out of16(31%) had haemoptysis. Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated with DAH has not been well described.","abstract_html":"Introduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopathological features of DAH and its management on the outcomes of children with this diagnosis. Methods: A descriptive study was conducted on children attending a tertiary centre pulmonology clinic from the period 2000-2022. A review of the clinical data, investigations and lung biopsy results was done and outcomes were reported. Results: Sixteen children were included in the study. The median age at presentation was 1.79 years (IQR 0.48-3.15). At presentation, the median haemoglobulin (Hb)was 5.4 (IQR 3.6-85). Five out of16(31%) had haemoptysis. Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated with DAH has not been well described.","abstract_has_math":false,"creators":["Masu, Adelaide Ngina"],"institution":"Department of Paediatrics and Child Health","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Vanker, Aneesa","Gray, Diane"],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025","date_published":"2025","updated_at":"2026-07-22T22:23:05Z","subjects":["Diffuse alveolar haemorrhage","Cape Town"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/42065","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Vanker, Aneesa","Gray, Diane"]},{"key":"dc:creator","label":"Author","values":["Masu, Adelaide Ngina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-10-30T12:22:13Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-10-30T12:22:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2025"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Paediatrics and Child Health"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Diffuse alveolar haemorrhage","Cape Town"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/42065"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Introduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopathological features of DAH and its management on the outcomes of children with this diagnosis. Methods: A descriptive study was conducted on children attending a tertiary centre pulmonology clinic from the period 2000-2022. A review of the clinical data, investigations and lung biopsy results was done and outcomes were reported. Results: Sixteen children were included in the study. The median age at presentation was 1.79 years (IQR 0.48-3.15). At presentation, the median haemoglobulin (Hb)was 5.4 (IQR 3.6-85). Five out of16(31%) had haemoptysis. Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated with DAH has not been well described."]},{"key":"dc:title","label":"Title","values":["MPhil in pulmonary haemorrhage in children in Cape Town"]}]}],"canonical_facts":{"dc:contributor.advisor":["Vanker, Aneesa","Gray, Diane"],"dc:creator":["Masu, Adelaide Ngina"],"dc:date.accessioned":["2025-10-30T12:22:13Z"],"dc:date.available":["2025-10-30T12:22:13Z"],"dc:date.issued":["2025"],"dc:description.abstract":["Introduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopathological features of DAH and its management on the outcomes of children with this diagnosis. Methods: A descriptive study was conducted on children attending a tertiary centre pulmonology clinic from the period 2000-2022. A review of the clinical data, investigations and lung biopsy results was done and outcomes were reported. Results: Sixteen children were included in the study. The median age at presentation was 1.79 years (IQR 0.48-3.15). At presentation, the median haemoglobulin (Hb)was 5.4 (IQR 3.6-85). Five out of16(31%) had haemoptysis. Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated with DAH has not been well described."],"dc:identifier.uri":["http://hdl.handle.net/11427/42065"],"dc:language.iso":["en"],"dc:publisher.department":["Department of Paediatrics and Child Health"],"dc:publisher.institution":["University of Cape Town"],"dc:subject":["Diffuse alveolar haemorrhage","Cape Town"],"dc:title":["MPhil in pulmonary haemorrhage in children in Cape Town"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Masters"]},"updated_at":"2026-07-22T22:23:05Z"}