{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/41680"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/41680","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment","abstract":"Shoulder pain and disability are common sequelae of breast cancer treatment in women, with an understated negative impact on the quality of life of affected individuals and a poorly characterised aetiology. A better understanding of the aetiology of shoulder pain and disability in breast cancer survivors is urgent to develop and/or integrate effective treatments to mitigate the related reduction in quality of life– this is especially important given the increasing cancer survivorship in societies such as in South Africa where a high percentage of households are female-headed and a resource-based public healthcare system is used by the majority. Previous studies have explored treatment-related and patient-related factors that modulate risk of upper-limb impairments in breast cancer survivors, including shoulder pain and disability. However, there is a paucity of relevant studies on key genetic factors. Genetic factors within angiogenesis-related signalling and extracellular matrix (ECM) regulating pathways have been implicated in non-cancer-related studies of soft tissue conditions of the shoulder that are associated with pain and display movement dysfunction similar to that seen in breast cancer post-treatment shoulder morbidity. It is largely unknown whether or not key factors within the angiogenesis-related and ECM-regulating signalling pathways may modulate risk of shoulder pain and disability in breast cancer survivors.","abstract_html":"Shoulder pain and disability are common sequelae of breast cancer treatment in women, with an understated negative impact on the quality of life of affected individuals and a poorly characterised aetiology. A better understanding of the aetiology of shoulder pain and disability in breast cancer survivors is urgent to develop and/or integrate effective treatments to mitigate the related reduction in quality of life– this is especially important given the increasing cancer survivorship in societies such as in South Africa where a high percentage of households are female-headed and a resource-based public healthcare system is used by the majority. Previous studies have explored treatment-related and patient-related factors that modulate risk of upper-limb impairments in breast cancer survivors, including shoulder pain and disability. However, there is a paucity of relevant studies on key genetic factors. Genetic factors within angiogenesis-related signalling and extracellular matrix (ECM) regulating pathways have been implicated in non-cancer-related studies of soft tissue conditions of the shoulder that are associated with pain and display movement dysfunction similar to that seen in breast cancer post-treatment shoulder morbidity. It is largely unknown whether or not key factors within the angiogenesis-related and ECM-regulating signalling pathways may modulate risk of shoulder pain and disability in breast cancer survivors.","abstract_has_math":false,"creators":["Mafu, Trevor"],"institution":"Department of Human Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Shamley, Delva","September, Alison"],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025","date_published":"2025","updated_at":"2026-07-22T22:23:12Z","subjects":["Breast cancer","South Africa","ECM"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/41680","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Shamley, Delva","September, Alison"]},{"key":"dc:creator","label":"Author","values":["Mafu, Trevor"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-09-02T11:58:18Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-09-02T11:58:18Z"]},{"key":"dc:date.issued","label":"Date","values":["2025"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Human Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral","PhD"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Breast cancer","South Africa","ECM"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/41680"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Shoulder pain and disability are common sequelae of breast cancer treatment in women, with an understated negative impact on the quality of life of affected individuals and a poorly characterised aetiology. A better understanding of the aetiology of shoulder pain and disability in breast cancer survivors is urgent to develop and/or integrate effective treatments to mitigate the related reduction in quality of life– this is especially important given the increasing cancer survivorship in societies such as in South Africa where a high percentage of households are female-headed and a resource-based public healthcare system is used by the majority. Previous studies have explored treatment-related and patient-related factors that modulate risk of upper-limb impairments in breast cancer survivors, including shoulder pain and disability. However, there is a paucity of relevant studies on key genetic factors. Genetic factors within angiogenesis-related signalling and extracellular matrix (ECM) regulating pathways have been implicated in non-cancer-related studies of soft tissue conditions of the shoulder that are associated with pain and display movement dysfunction similar to that seen in breast cancer post-treatment shoulder morbidity. It is largely unknown whether or not key factors within the angiogenesis-related and ECM-regulating signalling pathways may modulate risk of shoulder pain and disability in breast cancer survivors."]},{"key":"dc:title","label":"Title","values":["Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment"]}]}],"canonical_facts":{"dc:contributor.advisor":["Shamley, Delva","September, Alison"],"dc:creator":["Mafu, Trevor"],"dc:date.accessioned":["2025-09-02T11:58:18Z"],"dc:date.available":["2025-09-02T11:58:18Z"],"dc:date.issued":["2025"],"dc:description.abstract":["Shoulder pain and disability are common sequelae of breast cancer treatment in women, with an understated negative impact on the quality of life of affected individuals and a poorly characterised aetiology. A better understanding of the aetiology of shoulder pain and disability in breast cancer survivors is urgent to develop and/or integrate effective treatments to mitigate the related reduction in quality of life– this is especially important given the increasing cancer survivorship in societies such as in South Africa where a high percentage of households are female-headed and a resource-based public healthcare system is used by the majority. Previous studies have explored treatment-related and patient-related factors that modulate risk of upper-limb impairments in breast cancer survivors, including shoulder pain and disability. However, there is a paucity of relevant studies on key genetic factors. Genetic factors within angiogenesis-related signalling and extracellular matrix (ECM) regulating pathways have been implicated in non-cancer-related studies of soft tissue conditions of the shoulder that are associated with pain and display movement dysfunction similar to that seen in breast cancer post-treatment shoulder morbidity. It is largely unknown whether or not key factors within the angiogenesis-related and ECM-regulating signalling pathways may modulate risk of shoulder pain and disability in breast cancer survivors."],"dc:identifier.uri":["http://hdl.handle.net/11427/41680"],"dc:language.iso":["en"],"dc:publisher.department":["Department of Human Biology"],"dc:publisher.institution":["University of Cape Town"],"dc:subject":["Breast cancer","South Africa","ECM"],"dc:title":["Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Doctoral","PhD"]},"updated_at":"2026-07-22T22:23:12Z"}