{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/41654"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/41654","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers","abstract":"The spread of antimalarial drug resistance threatens global, regional and national malaria elimination efforts. Despite being preventable and treatable, malaria still claims over half a million lives globally, with over 95% of malaria cases and deaths occurring in Africa. Antimalarial drug resistance threatens progress in malaria control and elimination, especially in less-resourced health systems in developing countries. Malaria control and elimination efforts are facing stagnation of funding and competing resources with other potential pandemic pathogens like COVID-19, HIV, tuberculosis and non-communicable diseases. Regrettably, the malaria programmes and policymakers who are at the forefront of confronting antimalarial drug resistance often lack timely monitoring tools for evidence-based decision-making. This thesis used an iterative, sequential, explanatory, mixed-methods design to strengthen evidence on Plasmodium falciparum antimalarial drug resistance in Asia and South Africa. Through four thesis chapters of peer-reviewed manuscripts, the thesis presents innovative approaches to developing impactful policymaker-friendly tools for detection, reporting and responding to antimalarial drug resistance. Through co-design techniques, the thesis addresses major data challenges and developed guidelines and tools to support near-real-time antimalarial resistance monitoring. The thesis also highlights important processes and pinch points in rolling out an early warning system for antimalarial drug resistance in a pre- elimination setting in South Africa. This research contributes to best practices in summarising evidence for antimalarial drug resistance for policymakers and decision-makers. Furthermore, this thesis provides insights on the process of establishing an early warning system in a pre-elimination malaria setting, a context reflective of where several Southern African countries and Island states are heading in this decade.","abstract_html":"The spread of antimalarial drug resistance threatens global, regional and national malaria elimination efforts. Despite being preventable and treatable, malaria still claims over half a million lives globally, with over 95% of malaria cases and deaths occurring in Africa. Antimalarial drug resistance threatens progress in malaria control and elimination, especially in less-resourced health systems in developing countries. Malaria control and elimination efforts are facing stagnation of funding and competing resources with other potential pandemic pathogens like COVID-19, HIV, tuberculosis and non-communicable diseases. Regrettably, the malaria programmes and policymakers who are at the forefront of confronting antimalarial drug resistance often lack timely monitoring tools for evidence-based decision-making. This thesis used an iterative, sequential, explanatory, mixed-methods design to strengthen evidence on Plasmodium falciparum antimalarial drug resistance in Asia and South Africa. Through four thesis chapters of peer-reviewed manuscripts, the thesis presents innovative approaches to developing impactful policymaker-friendly tools for detection, reporting and responding to antimalarial drug resistance. Through co-design techniques, the thesis addresses major data challenges and developed guidelines and tools to support near-real-time antimalarial resistance monitoring. The thesis also highlights important processes and pinch points in rolling out an early warning system for antimalarial drug resistance in a pre- elimination setting in South Africa. This research contributes to best practices in summarising evidence for antimalarial drug resistance for policymakers and decision-makers. Furthermore, this thesis provides insights on the process of establishing an early warning system in a pre-elimination malaria setting, a context reflective of where several Southern African countries and Island states are heading in this decade.","abstract_has_math":false,"creators":["Kagoro, Frank"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Barnes, Karen"],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025","date_published":"2025","updated_at":"2026-07-22T22:23:16Z","subjects":["Antimalarial Drug","Malaria","Policymakers"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/41654","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Barnes, Karen"]},{"key":"dc:creator","label":"Author","values":["Kagoro, Frank"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-09-01T07:13:05Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-09-01T07:13:05Z"]},{"key":"dc:date.issued","label":"Date","values":["2025"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral","PhD"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Antimalarial Drug","Malaria","Policymakers"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/41654"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The spread of antimalarial drug resistance threatens global, regional and national malaria elimination efforts. Despite being preventable and treatable, malaria still claims over half a million lives globally, with over 95% of malaria cases and deaths occurring in Africa. Antimalarial drug resistance threatens progress in malaria control and elimination, especially in less-resourced health systems in developing countries. Malaria control and elimination efforts are facing stagnation of funding and competing resources with other potential pandemic pathogens like COVID-19, HIV, tuberculosis and non-communicable diseases. Regrettably, the malaria programmes and policymakers who are at the forefront of confronting antimalarial drug resistance often lack timely monitoring tools for evidence-based decision-making. This thesis used an iterative, sequential, explanatory, mixed-methods design to strengthen evidence on Plasmodium falciparum antimalarial drug resistance in Asia and South Africa. Through four thesis chapters of peer-reviewed manuscripts, the thesis presents innovative approaches to developing impactful policymaker-friendly tools for detection, reporting and responding to antimalarial drug resistance. Through co-design techniques, the thesis addresses major data challenges and developed guidelines and tools to support near-real-time antimalarial resistance monitoring. The thesis also highlights important processes and pinch points in rolling out an early warning system for antimalarial drug resistance in a pre- elimination setting in South Africa. This research contributes to best practices in summarising evidence for antimalarial drug resistance for policymakers and decision-makers. Furthermore, this thesis provides insights on the process of establishing an early warning system in a pre-elimination malaria setting, a context reflective of where several Southern African countries and Island states are heading in this decade."]},{"key":"dc:title","label":"Title","values":["Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers"]}]}],"canonical_facts":{"dc:contributor.advisor":["Barnes, Karen"],"dc:creator":["Kagoro, Frank"],"dc:date.accessioned":["2025-09-01T07:13:05Z"],"dc:date.available":["2025-09-01T07:13:05Z"],"dc:date.issued":["2025"],"dc:description.abstract":["The spread of antimalarial drug resistance threatens global, regional and national malaria elimination efforts. Despite being preventable and treatable, malaria still claims over half a million lives globally, with over 95% of malaria cases and deaths occurring in Africa. 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Through co-design techniques, the thesis addresses major data challenges and developed guidelines and tools to support near-real-time antimalarial resistance monitoring. The thesis also highlights important processes and pinch points in rolling out an early warning system for antimalarial drug resistance in a pre- elimination setting in South Africa. This research contributes to best practices in summarising evidence for antimalarial drug resistance for policymakers and decision-makers. 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