{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/41486"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/41486","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures","abstract":"Background: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact of HIV infection on bone mineral density (BMD) in HIV-positive individuals and compare this to the BMD in HIV-negative individuals with traumatic long-bone fractures. In addition, we compared the impact of demographics, nutritional (albumin), Vitamin D status and smoking between HIV-positive and negative individuals. Patients and Methods: We retrospectively reviewed data from a prospectively collected database within the HIV in Orthopaedic Skeletal Trauma (HOST) study conducted at tertiary care hospitals. This study included all individuals with a confirmed HIV positive or negative status who had their BMD measurement performed using a calcaneal quantitative ultrasound scan (cQUS) and excluded those individuals who had never had a cQUS performed. Results: Of 400 individuals recruited from the parent study, 172 (43%) had their BMD measured. 27(15.7%) were HIV-positive. Overall, the BMD and T-scores were similar in both the HIV-positive and HIV-negative participants with a median BMD of 0.49 g/cm2 (0.23 – 0.71) within the HIV positive group; 0.49 (0.3-0.71) within the HIV negative group and an overall T-score of -0.8, with no statistical significance found between the two groups (p>0.050). Age, smoking status, Vitamin D, Albumin and BMI had no effect on BMD (p> 0.050). Conclusion: We found a higher proportion of patients with osteoporosis within the HIV-positive cohort, although not statistically significant and no statistically significant difference in the median BMD between the HIV -positive and HIVnegative subgroups. Neither age, smoking, vitamin D, albumin nor BMI was associated with a lower BMD","abstract_html":"Background: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact of HIV infection on bone mineral density (BMD) in HIV-positive individuals and compare this to the BMD in HIV-negative individuals with traumatic long-bone fractures. In addition, we compared the impact of demographics, nutritional (albumin), Vitamin D status and smoking between HIV-positive and negative individuals. Patients and Methods: We retrospectively reviewed data from a prospectively collected database within the HIV in Orthopaedic Skeletal Trauma (HOST) study conducted at tertiary care hospitals. This study included all individuals with a confirmed HIV positive or negative status who had their BMD measurement performed using a calcaneal quantitative ultrasound scan (cQUS) and excluded those individuals who had never had a cQUS performed. Results: Of 400 individuals recruited from the parent study, 172 (43%) had their BMD measured. 27(15.7%) were HIV-positive. Overall, the BMD and T-scores were similar in both the HIV-positive and HIV-negative participants with a median BMD of 0.49 g/cm2 (0.23 – 0.71) within the HIV positive group; 0.49 (0.3-0.71) within the HIV negative group and an overall T-score of -0.8, with no statistical significance found between the two groups (p>0.050). Age, smoking status, Vitamin D, Albumin and BMI had no effect on BMD (p> 0.050). Conclusion: We found a higher proportion of patients with osteoporosis within the HIV-positive cohort, although not statistically significant and no statistically significant difference in the median BMD between the HIV -positive and HIVnegative subgroups. Neither age, smoking, vitamin D, albumin nor BMI was associated with a lower BMD","abstract_has_math":false,"creators":["Botha, Peter"],"institution":"Division of General Surgery","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Laubscher, Maritz","Maqungo Sithombo"],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025","date_published":"2025","updated_at":"2026-07-24T01:34:13Z","subjects":["General Surgery"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/41486","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Laubscher, Maritz","Maqungo Sithombo"]},{"key":"dc:creator","label":"Author","values":["Botha, Peter"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-06-25T11:51:10Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-06-25T11:51:10Z"]},{"key":"dc:date.issued","label":"Date","values":["2025"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of General Surgery"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape town"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters","MMed"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["General Surgery"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/41486"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact of HIV infection on bone mineral density (BMD) in HIV-positive individuals and compare this to the BMD in HIV-negative individuals with traumatic long-bone fractures. In addition, we compared the impact of demographics, nutritional (albumin), Vitamin D status and smoking between HIV-positive and negative individuals. Patients and Methods: We retrospectively reviewed data from a prospectively collected database within the HIV in Orthopaedic Skeletal Trauma (HOST) study conducted at tertiary care hospitals. This study included all individuals with a confirmed HIV positive or negative status who had their BMD measurement performed using a calcaneal quantitative ultrasound scan (cQUS) and excluded those individuals who had never had a cQUS performed. Results: Of 400 individuals recruited from the parent study, 172 (43%) had their BMD measured. 27(15.7%) were HIV-positive. Overall, the BMD and T-scores were similar in both the HIV-positive and HIV-negative participants with a median BMD of 0.49 g/cm2 (0.23 – 0.71) within the HIV positive group; 0.49 (0.3-0.71) within the HIV negative group and an overall T-score of -0.8, with no statistical significance found between the two groups (p>0.050). Age, smoking status, Vitamin D, Albumin and BMI had no effect on BMD (p> 0.050). Conclusion: We found a higher proportion of patients with osteoporosis within the HIV-positive cohort, although not statistically significant and no statistically significant difference in the median BMD between the HIV -positive and HIVnegative subgroups. Neither age, smoking, vitamin D, albumin nor BMI was associated with a lower BMD"]},{"key":"dc:title","label":"Title","values":["Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures"]}]}],"canonical_facts":{"dc:contributor.advisor":["Laubscher, Maritz","Maqungo Sithombo"],"dc:creator":["Botha, Peter"],"dc:date.accessioned":["2025-06-25T11:51:10Z"],"dc:date.available":["2025-06-25T11:51:10Z"],"dc:date.issued":["2025"],"dc:description.abstract":["Background: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact of HIV infection on bone mineral density (BMD) in HIV-positive individuals and compare this to the BMD in HIV-negative individuals with traumatic long-bone fractures. In addition, we compared the impact of demographics, nutritional (albumin), Vitamin D status and smoking between HIV-positive and negative individuals. Patients and Methods: We retrospectively reviewed data from a prospectively collected database within the HIV in Orthopaedic Skeletal Trauma (HOST) study conducted at tertiary care hospitals. This study included all individuals with a confirmed HIV positive or negative status who had their BMD measurement performed using a calcaneal quantitative ultrasound scan (cQUS) and excluded those individuals who had never had a cQUS performed. Results: Of 400 individuals recruited from the parent study, 172 (43%) had their BMD measured. 27(15.7%) were HIV-positive. Overall, the BMD and T-scores were similar in both the HIV-positive and HIV-negative participants with a median BMD of 0.49 g/cm2 (0.23 – 0.71) within the HIV positive group; 0.49 (0.3-0.71) within the HIV negative group and an overall T-score of -0.8, with no statistical significance found between the two groups (p>0.050). Age, smoking status, Vitamin D, Albumin and BMI had no effect on BMD (p> 0.050). Conclusion: We found a higher proportion of patients with osteoporosis within the HIV-positive cohort, although not statistically significant and no statistically significant difference in the median BMD between the HIV -positive and HIVnegative subgroups. Neither age, smoking, vitamin D, albumin nor BMI was associated with a lower BMD"],"dc:identifier.uri":["http://hdl.handle.net/11427/41486"],"dc:publisher.department":["Division of General Surgery"],"dc:publisher.institution":["University of Cape town"],"dc:subject":["General Surgery"],"dc:title":["Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Masters","MMed"]},"updated_at":"2026-07-24T01:34:13Z"}