{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/41294"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/41294","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The intersection of the HIV epidemic and blood donation in South Africa","abstract":"South Africa's large population of people living with HIV (PLWH) affects the local blood transfusion services (BTS) in multiple ways, including the recruitment of safe donors, the demand for blood and the development of blood safety policies. The latter includes the deferral of persons at risk of recently acquired HIV and sensitive testing for HIV antibodies and RNA. Estimating HIV incidence in blood donors is a key measure of successful prevention strategies. Blood donation by PLWH on antiretroviral therapy (ART) was identified as an emerging risk to blood safety as early ART initiation may result in delayed seroconversion, seroreversion, and prolonged suppression of viral replication which may escape detection by HIV antibody and nucleic acid amplification testing (NAT). My PhD research used epidemiologic, incidence modelling and mixed-method qualitative research techniques to assess the impact of undisclosed ART use among blood donors on the safety of the country's blood supply.","abstract_html":"South Africa's large population of people living with HIV (PLWH) affects the local blood transfusion services (BTS) in multiple ways, including the recruitment of safe donors, the demand for blood and the development of blood safety policies. The latter includes the deferral of persons at risk of recently acquired HIV and sensitive testing for HIV antibodies and RNA. Estimating HIV incidence in blood donors is a key measure of successful prevention strategies. Blood donation by PLWH on antiretroviral therapy (ART) was identified as an emerging risk to blood safety as early ART initiation may result in delayed seroconversion, seroreversion, and prolonged suppression of viral replication which may escape detection by HIV antibody and nucleic acid amplification testing (NAT). My PhD research used epidemiologic, incidence modelling and mixed-method qualitative research techniques to assess the impact of undisclosed ART use among blood donors on the safety of the country's blood supply.","abstract_has_math":false,"creators":["Van Den Berg, Karin"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Louw, Vernon","Maartens, Gary","Murphy, Edward","Hughes, Shana"],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024","date_published":"2024","updated_at":"2026-07-22T22:23:22Z","subjects":["HIV","Blood donation"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/41294","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Louw, Vernon","Maartens, Gary","Murphy, Edward","Hughes, Shana"]},{"key":"dc:creator","label":"Author","values":["Van Den Berg, Karin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-03-31T07:33:45Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-03-31T07:33:45Z"]},{"key":"dc:date.issued","label":"Date","values":["2024"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral","PhD"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["HIV","Blood donation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/41294"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["South Africa's large population of people living with HIV (PLWH) affects the local blood transfusion services (BTS) in multiple ways, including the recruitment of safe donors, the demand for blood and the development of blood safety policies. The latter includes the deferral of persons at risk of recently acquired HIV and sensitive testing for HIV antibodies and RNA. Estimating HIV incidence in blood donors is a key measure of successful prevention strategies. Blood donation by PLWH on antiretroviral therapy (ART) was identified as an emerging risk to blood safety as early ART initiation may result in delayed seroconversion, seroreversion, and prolonged suppression of viral replication which may escape detection by HIV antibody and nucleic acid amplification testing (NAT). My PhD research used epidemiologic, incidence modelling and mixed-method qualitative research techniques to assess the impact of undisclosed ART use among blood donors on the safety of the country's blood supply."]},{"key":"dc:title","label":"Title","values":["The intersection of the HIV epidemic and blood donation in South Africa"]}]}],"canonical_facts":{"dc:contributor.advisor":["Louw, Vernon","Maartens, Gary","Murphy, Edward","Hughes, Shana"],"dc:creator":["Van Den Berg, Karin"],"dc:date.accessioned":["2025-03-31T07:33:45Z"],"dc:date.available":["2025-03-31T07:33:45Z"],"dc:date.issued":["2024"],"dc:description.abstract":["South Africa's large population of people living with HIV (PLWH) affects the local blood transfusion services (BTS) in multiple ways, including the recruitment of safe donors, the demand for blood and the development of blood safety policies. The latter includes the deferral of persons at risk of recently acquired HIV and sensitive testing for HIV antibodies and RNA. Estimating HIV incidence in blood donors is a key measure of successful prevention strategies. Blood donation by PLWH on antiretroviral therapy (ART) was identified as an emerging risk to blood safety as early ART initiation may result in delayed seroconversion, seroreversion, and prolonged suppression of viral replication which may escape detection by HIV antibody and nucleic acid amplification testing (NAT). My PhD research used epidemiologic, incidence modelling and mixed-method qualitative research techniques to assess the impact of undisclosed ART use among blood donors on the safety of the country's blood supply."],"dc:identifier.uri":["http://hdl.handle.net/11427/41294"],"dc:language.iso":["en"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:subject":["HIV","Blood donation"],"dc:title":["The intersection of the HIV epidemic and blood donation in South Africa"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Doctoral","PhD"]},"updated_at":"2026-07-22T22:23:22Z"}