Synthesis, characterization, and anticancer activity of arene mono-ruthenium and heteroleptic mixed-valent diruthenium complexes
type: CreativeWork
description: To contribute towards the good health and well-being sustainable development goal, this project aims to synthesize and characterize organometallic arene mono-ruthenium and diruthenium complexes that have anti-neoplastic properties against the oestrogen receptor positive MCF-7, and the triple negative aggressive and invasive MDA-MB-231 human breast cancer cell lines. The preparation of diruthenium complexes led to the formation of paddlewheel-type complexes having a general chemical formula [Ru2(O2CCH3)3(R-ap)Cl] (C1 - C8). On the other hand, the preparation of mono-ruthenium complexes led to the formation of the complexes [RuCl2(η6 - C6H5OCH2CH2OH)(R)] (C10 - C12), and the novel [RuCl(η6 - C6H5OCH2CH2OH)(P(OPh)3)(SnCl3)] (C13 and C14). All complexes were characterized using spectroscopic techniques such as IR, UV-visible, 1-D and 2-D NMR. The connectivity of atoms through space as well as the solid-state structures was confirmed using X-ray crystallography. The purity of all synthesized compounds was confirmed by high-resolution mass spectrometry (HR-MS), hyphenated chromatographic techniques (LC-MS) as well as melting points. Magnetic susceptibility studies were conducted to determine and confirm the number of unpaired electrons of the paramagnetic bimetallic complexes. Due to their mixed valent Ru2(II, III) metalcore, cyclic voltammetry measurements were recorded to study the redox behaviour of the investigated complexes. The cytotoxic experiments performed against human breast MCF-7 and MDA-MB-231 cancer cells suggest that all free anilinopyridinate (R-ap) ligands do not significantly inhibit the survival growth of both cell lines, whereas coordination of these ligands to a Ru2(II, III) metal-core to form [Ru2(O2CCH3)3(R-ap)Cl] complexes (where R = CH3 or F) improves the anticancer activity against the afore-mentioned human breast cancer cells. Anilinopyridinate-type ligands were synthesized through a facile nucleophilic aromatic substitution reaction between 2-b…
abstract: To contribute towards the good health and well-being sustainable development goal, this project aims to synthesize and characterize organometallic arene mono-ruthenium and diruthenium complexes that have anti-neoplastic properties against the oestrogen receptor positive MCF-7, and the triple negative aggressive and invasive MDA-MB-231 human breast cancer cell lines. The preparation of diruthenium complexes led to the formation of paddlewheel-type complexes having a general chemical formula [Ru2(O2CCH3)3(R-ap)Cl] (C1 - C8). On the other hand, the preparation of mono-ruthenium complexes led to the formation of the complexes [RuCl2(η6 - C6H5OCH2CH2OH)(R)] (C10 - C12), and the novel [RuCl(η6 - C6H5OCH2CH2OH)(P(OPh)3)(SnCl3)] (C13 and C14). All complexes were characterized using spectroscopic techniques such as IR, UV-visible, 1-D and 2-D NMR. The connectivity of atoms through space as well as the solid-state structures was confirmed using X-ray crystallography. The purity of all synthesized compounds was confirmed by high-resolution mass spectrometry (HR-MS), hyphenated chromatographic techniques (LC-MS) as well as melting points. Magnetic susceptibility studies were conducted to determine and confirm the number of unpaired electrons of the paramagnetic bimetallic complexes. Due to their mixed valent Ru2(II, III) metalcore, cyclic voltammetry measurements were recorded to study the redox behaviour of the investigated complexes. The cytotoxic experiments performed against human breast MCF-7 and MDA-MB-231 cancer cells suggest that all free anilinopyridinate (R-ap) ligands do not significantly inhibit the survival growth of both cell lines, whereas coordination of these ligands to a Ru2(II, III) metal-core to form [Ru2(O2CCH3)3(R-ap)Cl] complexes (where R = CH3 or F) improves the anticancer activity against the afore-mentioned human breast cancer cells. Anilinopyridinate-type ligands were synthesized through a facile nucleophilic aromatic substitution reaction between 2-b…
author: Medupe, Thato Tshwaro
language: en
keywords: chemistry
date published: 2024
date modified: 2026-07-22T22:23:13Z
provider: University of Cape Town
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Department of Chemistry

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property ID: Handle
value: http://hdl.handle.net/11427/41067