{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/40516"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/40516","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Development and study of a monoclonal antibody to the human HLA-class II invariant chain","abstract":"The work I present in this thesis was initiated by a request for a monoclonal antibody (MoAb) to the peripheral blood cells of a patient with chronic lymphocytic leukemia (CLL). It was initially hoped that such an antibody, if directed against an idiotypic determinant on the malignant B-cell surface, may prove to be useful therapeutically by virtue of its specificity and limited reactivity. 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