{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/40260"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/40260","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance","abstract":"Patients with impaired left ventricular function have a poor prognosis. Those with three vessel coronary artery disease who successfully undergo revascularisation have a better outlook but their peri-operative risk is high. Viable myocardium with impaired coronary flow reserve and impaired contractility recovers function following revascularisation and the preoperative identification of this \"hibernating myocardium\" helps to select those patients most likely to benefit from surgery. The accurate differentiation of hibernating tissue from full thickness myocardial scar is important as the choice of the correct treatment for patients with or without evidence of hibernation has important prognostic implications. This work comprises five studies which evaluate the comparison of imaging techniques for the identification of myocardial hibernation, the histological features which characterise hibernating tissue when compared to normal myocardium or scar, and the relationship of histology to imaging characteristics, and finally the clinical impact of revascularising hibernating myocardium when compared with medical treatment alone.","abstract_html":"Patients with impaired left ventricular function have a poor prognosis. Those with three vessel coronary artery disease who successfully undergo revascularisation have a better outlook but their peri-operative risk is high. Viable myocardium with impaired coronary flow reserve and impaired contractility recovers function following revascularisation and the preoperative identification of this "hibernating myocardium" helps to select those patients most likely to benefit from surgery. The accurate differentiation of hibernating tissue from full thickness myocardial scar is important as the choice of the correct treatment for patients with or without evidence of hibernation has important prognostic implications. This work comprises five studies which evaluate the comparison of imaging techniques for the identification of myocardial hibernation, the histological features which characterise hibernating tissue when compared to normal myocardium or scar, and the relationship of histology to imaging characteristics, and finally the clinical impact of revascularising hibernating myocardium when compared with medical treatment alone.","abstract_has_math":false,"creators":["Gunning, Mark Gerard"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1999,"date_issued":"1999","date_published":"1999","updated_at":"2026-07-22T22:23:10Z","subjects":["Medicine"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/40260","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Gunning, Mark Gerard"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-07-04T13:35:16Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-07-04T13:35:16Z"]},{"key":"dc:date.issued","label":"Date","values":["1999"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral","MD"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Medicine"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/40260"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Patients with impaired left ventricular function have a poor prognosis. Those with three vessel coronary artery disease who successfully undergo revascularisation have a better outlook but their peri-operative risk is high. Viable myocardium with impaired coronary flow reserve and impaired contractility recovers function following revascularisation and the preoperative identification of this \"hibernating myocardium\" helps to select those patients most likely to benefit from surgery. The accurate differentiation of hibernating tissue from full thickness myocardial scar is important as the choice of the correct treatment for patients with or without evidence of hibernation has important prognostic implications. This work comprises five studies which evaluate the comparison of imaging techniques for the identification of myocardial hibernation, the histological features which characterise hibernating tissue when compared to normal myocardium or scar, and the relationship of histology to imaging characteristics, and finally the clinical impact of revascularising hibernating myocardium when compared with medical treatment alone."]},{"key":"dc:title","label":"Title","values":["The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance"]}]}],"canonical_facts":{"dc:creator":["Gunning, Mark Gerard"],"dc:date.accessioned":["2024-07-04T13:35:16Z"],"dc:date.available":["2024-07-04T13:35:16Z"],"dc:date.issued":["1999"],"dc:description.abstract":["Patients with impaired left ventricular function have a poor prognosis. Those with three vessel coronary artery disease who successfully undergo revascularisation have a better outlook but their peri-operative risk is high. Viable myocardium with impaired coronary flow reserve and impaired contractility recovers function following revascularisation and the preoperative identification of this \"hibernating myocardium\" helps to select those patients most likely to benefit from surgery. The accurate differentiation of hibernating tissue from full thickness myocardial scar is important as the choice of the correct treatment for patients with or without evidence of hibernation has important prognostic implications. This work comprises five studies which evaluate the comparison of imaging techniques for the identification of myocardial hibernation, the histological features which characterise hibernating tissue when compared to normal myocardium or scar, and the relationship of histology to imaging characteristics, and finally the clinical impact of revascularising hibernating myocardium when compared with medical treatment alone."],"dc:identifier.uri":["http://hdl.handle.net/11427/40260"],"dc:publisher.department":["Department of Medicine"],"dc:subject":["Medicine"],"dc:title":["The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Doctoral","MD"]},"updated_at":"2026-07-22T22:23:10Z"}