{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/39884"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/39884","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Outcomes of penetrating keratoplasty at a tertiary institution in South Africa.","abstract":"Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February 2019. Results: The mean age of study participants was 38 years (14-85). The study included 60% females and 40% males. The main indications for surgery were keratoconus (58%), corneal scar (21%), regrafts (8%), pseudophakic bullous keratopathy (6%), corneal dystrophies (3%) and pellucid marginal degeneration (1%). The overall graft survival at 1-year follow up was 86%. A higher 1-year graft survival rate of 94% was seen in patients with keratoconus. The total number of patients diagnosed with graft failure at 1 year was 13.The Kaplan-Meier survival analysis was used to assess time to graft failure. The estimate was 11.7 months (mean time to graft failure) with a 95% CI confidence interval from 11.4 to 12 months. In our study, best corrected Snellen acuity in the category of 6/6-6/18 was found in 59.2% of patients 1-one year post-operatively, compared with 1% of patients in the same BCVA group pre-operatively. Patients with a BCVA equal to 3/60 or less reduced from 56% preoperatively to 20% postoperatively at 1 one year. Conclusion: Penetrating Keratoplasty is an effective long term treatment option to restore visual acuity in certain corneal disorders in a middle to low-income country. Our results demonstrated a comparable 1-year graft survival rate to high-income countries.","abstract_html":"Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February 2019. Results: The mean age of study participants was 38 years (14-85). The study included 60% females and 40% males. The main indications for surgery were keratoconus (58%), corneal scar (21%), regrafts (8%), pseudophakic bullous keratopathy (6%), corneal dystrophies (3%) and pellucid marginal degeneration (1%). The overall graft survival at 1-year follow up was 86%. A higher 1-year graft survival rate of 94% was seen in patients with keratoconus. The total number of patients diagnosed with graft failure at 1 year was 13.The Kaplan-Meier survival analysis was used to assess time to graft failure. The estimate was 11.7 months (mean time to graft failure) with a 95% CI confidence interval from 11.4 to 12 months. In our study, best corrected Snellen acuity in the category of 6/6-6/18 was found in 59.2% of patients 1-one year post-operatively, compared with 1% of patients in the same BCVA group pre-operatively. Patients with a BCVA equal to 3/60 or less reduced from 56% preoperatively to 20% postoperatively at 1 one year. Conclusion: Penetrating Keratoplasty is an effective long term treatment option to restore visual acuity in certain corneal disorders in a middle to low-income country. Our results demonstrated a comparable 1-year graft survival rate to high-income countries.","abstract_has_math":false,"creators":["Theron, Yolande"],"institution":"Division of General Surgery","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["du Toit, Nagib"],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023","date_published":"2023","updated_at":"2026-07-22T22:22:58Z","subjects":["General Surgery"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/39884","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["du Toit, Nagib"]},{"key":"dc:creator","label":"Author","values":["Theron, Yolande"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-06-06T09:50:48Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-06-06T09:50:48Z"]},{"key":"dc:date.issued","label":"Date","values":["2023"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of General Surgery"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters","MMed"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["General Surgery"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/39884"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February 2019. Results: The mean age of study participants was 38 years (14-85). The study included 60% females and 40% males. The main indications for surgery were keratoconus (58%), corneal scar (21%), regrafts (8%), pseudophakic bullous keratopathy (6%), corneal dystrophies (3%) and pellucid marginal degeneration (1%). The overall graft survival at 1-year follow up was 86%. A higher 1-year graft survival rate of 94% was seen in patients with keratoconus. The total number of patients diagnosed with graft failure at 1 year was 13.The Kaplan-Meier survival analysis was used to assess time to graft failure. The estimate was 11.7 months (mean time to graft failure) with a 95% CI confidence interval from 11.4 to 12 months. In our study, best corrected Snellen acuity in the category of 6/6-6/18 was found in 59.2% of patients 1-one year post-operatively, compared with 1% of patients in the same BCVA group pre-operatively. Patients with a BCVA equal to 3/60 or less reduced from 56% preoperatively to 20% postoperatively at 1 one year. Conclusion: Penetrating Keratoplasty is an effective long term treatment option to restore visual acuity in certain corneal disorders in a middle to low-income country. Our results demonstrated a comparable 1-year graft survival rate to high-income countries."]},{"key":"dc:title","label":"Title","values":["Outcomes of penetrating keratoplasty at a tertiary institution in South Africa."]}]}],"canonical_facts":{"dc:contributor.advisor":["du Toit, Nagib"],"dc:creator":["Theron, Yolande"],"dc:date.accessioned":["2024-06-06T09:50:48Z"],"dc:date.available":["2024-06-06T09:50:48Z"],"dc:date.issued":["2023"],"dc:description.abstract":["Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February 2019. Results: The mean age of study participants was 38 years (14-85). The study included 60% females and 40% males. The main indications for surgery were keratoconus (58%), corneal scar (21%), regrafts (8%), pseudophakic bullous keratopathy (6%), corneal dystrophies (3%) and pellucid marginal degeneration (1%). The overall graft survival at 1-year follow up was 86%. A higher 1-year graft survival rate of 94% was seen in patients with keratoconus. The total number of patients diagnosed with graft failure at 1 year was 13.The Kaplan-Meier survival analysis was used to assess time to graft failure. The estimate was 11.7 months (mean time to graft failure) with a 95% CI confidence interval from 11.4 to 12 months. In our study, best corrected Snellen acuity in the category of 6/6-6/18 was found in 59.2% of patients 1-one year post-operatively, compared with 1% of patients in the same BCVA group pre-operatively. Patients with a BCVA equal to 3/60 or less reduced from 56% preoperatively to 20% postoperatively at 1 one year. Conclusion: Penetrating Keratoplasty is an effective long term treatment option to restore visual acuity in certain corneal disorders in a middle to low-income country. Our results demonstrated a comparable 1-year graft survival rate to high-income countries."],"dc:identifier.uri":["http://hdl.handle.net/11427/39884"],"dc:publisher.department":["Division of General Surgery"],"dc:subject":["General Surgery"],"dc:title":["Outcomes of penetrating keratoplasty at a tertiary institution in South Africa."],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Masters","MMed"]},"updated_at":"2026-07-22T22:22:58Z"}