{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/39758"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/39758","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa","abstract":"Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe the nutritional outcomes of children following liver transplantation. Methods: A retrospective study of patient's receiving post-transplant care at Red Cross War Memorial Children's Hospital in Cape Town, South Africa from 2004 – 2019. Results: 31 children were included in the analysis. Pre-transplant prevalence of stunting was 57,1%, with 32,1% of children severely stunted. At 24 months post-transplant 65,5% of children were stunted, with 44,8% severely stunted. Overweight and obesity prevalence was 0% pretransplant, and 32,2% and 27,6% at 12- and 24-months post-transplant respectively. Biliary atresia was the diagnosis in 89,5% of children with stunting at 24 months vs in 50% of children without stunting at 24 months post-transplant (p = 0.03). Mean pre-transplant albumin was lower in children with stunting at 24 months post-transplant than in children without stunting (26,7 vs 29,6 g/L respectively; p < 0,001). Age at transplant was lower in children with stunting at 24 months post-transplant vs children without stunting (40,7 versus 91,5 months; p < 0.001). Twenty-one (67,7%) children developed hypertension post-transplant. Conclusion: Stunting, hypertension and overweight/obesity are highly prevalent post paediatric liver transplantation. Lower pre-transplant albumin, younger age at transplant, and diagnosis of biliary atresia were associated with post-transplant stunting. Post-transplant growth monitoring seems prudent to prevent the development of overnutrition and associated metabolic complications.","abstract_html":"Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe the nutritional outcomes of children following liver transplantation. Methods: A retrospective study of patient&#x27;s receiving post-transplant care at Red Cross War Memorial Children&#x27;s Hospital in Cape Town, South Africa from 2004 – 2019. Results: 31 children were included in the analysis. Pre-transplant prevalence of stunting was 57,1%, with 32,1% of children severely stunted. At 24 months post-transplant 65,5% of children were stunted, with 44,8% severely stunted. Overweight and obesity prevalence was 0% pretransplant, and 32,2% and 27,6% at 12- and 24-months post-transplant respectively. Biliary atresia was the diagnosis in 89,5% of children with stunting at 24 months vs in 50% of children without stunting at 24 months post-transplant (p = 0.03). Mean pre-transplant albumin was lower in children with stunting at 24 months post-transplant than in children without stunting (26,7 vs 29,6 g/L respectively; p &lt; 0,001). Age at transplant was lower in children with stunting at 24 months post-transplant vs children without stunting (40,7 versus 91,5 months; p &lt; 0.001). Twenty-one (67,7%) children developed hypertension post-transplant. Conclusion: Stunting, hypertension and overweight/obesity are highly prevalent post paediatric liver transplantation. Lower pre-transplant albumin, younger age at transplant, and diagnosis of biliary atresia were associated with post-transplant stunting. Post-transplant growth monitoring seems prudent to prevent the development of overnutrition and associated metabolic complications.","abstract_has_math":false,"creators":["Ndhlovu, Lesego"],"institution":"Department of Paediatrics and Child Health","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["de Lacy, Ronalda"],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023","date_published":"2023","updated_at":"2026-07-22T22:23:21Z","subjects":["Paediatric Gastroenterology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/39758","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["de Lacy, Ronalda"]},{"key":"dc:creator","label":"Author","values":["Ndhlovu, Lesego"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-05-30T09:41:07Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-05-30T09:41:07Z"]},{"key":"dc:date.issued","label":"Date","values":["2023"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Paediatrics and Child Health"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters","MPhil"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Paediatric Gastroenterology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/39758"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe the nutritional outcomes of children following liver transplantation. Methods: A retrospective study of patient's receiving post-transplant care at Red Cross War Memorial Children's Hospital in Cape Town, South Africa from 2004 – 2019. Results: 31 children were included in the analysis. Pre-transplant prevalence of stunting was 57,1%, with 32,1% of children severely stunted. At 24 months post-transplant 65,5% of children were stunted, with 44,8% severely stunted. Overweight and obesity prevalence was 0% pretransplant, and 32,2% and 27,6% at 12- and 24-months post-transplant respectively. Biliary atresia was the diagnosis in 89,5% of children with stunting at 24 months vs in 50% of children without stunting at 24 months post-transplant (p = 0.03). Mean pre-transplant albumin was lower in children with stunting at 24 months post-transplant than in children without stunting (26,7 vs 29,6 g/L respectively; p < 0,001). Age at transplant was lower in children with stunting at 24 months post-transplant vs children without stunting (40,7 versus 91,5 months; p < 0.001). Twenty-one (67,7%) children developed hypertension post-transplant. Conclusion: Stunting, hypertension and overweight/obesity are highly prevalent post paediatric liver transplantation. Lower pre-transplant albumin, younger age at transplant, and diagnosis of biliary atresia were associated with post-transplant stunting. Post-transplant growth monitoring seems prudent to prevent the development of overnutrition and associated metabolic complications."]},{"key":"dc:title","label":"Title","values":["Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa"]}]}],"canonical_facts":{"dc:contributor.advisor":["de Lacy, Ronalda"],"dc:creator":["Ndhlovu, Lesego"],"dc:date.accessioned":["2024-05-30T09:41:07Z"],"dc:date.available":["2024-05-30T09:41:07Z"],"dc:date.issued":["2023"],"dc:description.abstract":["Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe the nutritional outcomes of children following liver transplantation. Methods: A retrospective study of patient's receiving post-transplant care at Red Cross War Memorial Children's Hospital in Cape Town, South Africa from 2004 – 2019. Results: 31 children were included in the analysis. Pre-transplant prevalence of stunting was 57,1%, with 32,1% of children severely stunted. At 24 months post-transplant 65,5% of children were stunted, with 44,8% severely stunted. Overweight and obesity prevalence was 0% pretransplant, and 32,2% and 27,6% at 12- and 24-months post-transplant respectively. Biliary atresia was the diagnosis in 89,5% of children with stunting at 24 months vs in 50% of children without stunting at 24 months post-transplant (p = 0.03). Mean pre-transplant albumin was lower in children with stunting at 24 months post-transplant than in children without stunting (26,7 vs 29,6 g/L respectively; p < 0,001). Age at transplant was lower in children with stunting at 24 months post-transplant vs children without stunting (40,7 versus 91,5 months; p < 0.001). Twenty-one (67,7%) children developed hypertension post-transplant. Conclusion: Stunting, hypertension and overweight/obesity are highly prevalent post paediatric liver transplantation. Lower pre-transplant albumin, younger age at transplant, and diagnosis of biliary atresia were associated with post-transplant stunting. Post-transplant growth monitoring seems prudent to prevent the development of overnutrition and associated metabolic complications."],"dc:identifier.uri":["http://hdl.handle.net/11427/39758"],"dc:publisher.department":["Department of Paediatrics and Child Health"],"dc:subject":["Paediatric Gastroenterology"],"dc:title":["Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Masters","MPhil"]},"updated_at":"2026-07-22T22:23:21Z"}