{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/39301"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/39301","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital","abstract":"Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, especially in the Western Cape. Objective. This study aims to describe a case series of newborns with iGBS in a tertiary hospital in the Western Cape. Methods. A retrospective folder review was conducted between January 2015 and December 2020. Results. Thirty five cases of invasive GBS disease were included in the study, 51% with earlyonset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups respectively. The median birth weight was 900 g and 1812 g in the LoD and EoD group respectively. Meningits was more common in the LoD group, and pneumonia more common in the EoD group. The overall mortality rate was 23%, and GBS disease accounted for a cumulative 274 days in the intensive care unit. Conclusion. Invasive GBS disease in newborns at GSH carries a high mortality rate with a similar burden of LoD and EoD. More studies of newborn iGBS are needed in the Western Cape and South Africa to better understand the burden of disease.","abstract_html":"Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, especially in the Western Cape. Objective. This study aims to describe a case series of newborns with iGBS in a tertiary hospital in the Western Cape. Methods. A retrospective folder review was conducted between January 2015 and December 2020. Results. Thirty five cases of invasive GBS disease were included in the study, 51% with earlyonset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups respectively. The median birth weight was 900 g and 1812 g in the LoD and EoD group respectively. Meningits was more common in the LoD group, and pneumonia more common in the EoD group. The overall mortality rate was 23%, and GBS disease accounted for a cumulative 274 days in the intensive care unit. Conclusion. Invasive GBS disease in newborns at GSH carries a high mortality rate with a similar burden of LoD and EoD. More studies of newborn iGBS are needed in the Western Cape and South Africa to better understand the burden of disease.","abstract_has_math":false,"creators":["Browne, Bradley"],"institution":"Department of Paediatrics and Child Health","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Tooke, Lloyd"],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023","date_published":"2023","updated_at":"2026-07-22T22:23:14Z","subjects":["Paediatrics"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/39301","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Tooke, Lloyd"]},{"key":"dc:creator","label":"Author","values":["Browne, Bradley"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-04-04T08:15:03Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-04-04T08:15:03Z"]},{"key":"dc:date.issued","label":"Date","values":["2023"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Paediatrics and Child Health"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters","MMed"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Paediatrics"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/39301"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, especially in the Western Cape. Objective. This study aims to describe a case series of newborns with iGBS in a tertiary hospital in the Western Cape. Methods. A retrospective folder review was conducted between January 2015 and December 2020. Results. Thirty five cases of invasive GBS disease were included in the study, 51% with earlyonset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups respectively. The median birth weight was 900 g and 1812 g in the LoD and EoD group respectively. Meningits was more common in the LoD group, and pneumonia more common in the EoD group. The overall mortality rate was 23%, and GBS disease accounted for a cumulative 274 days in the intensive care unit. Conclusion. Invasive GBS disease in newborns at GSH carries a high mortality rate with a similar burden of LoD and EoD. More studies of newborn iGBS are needed in the Western Cape and South Africa to better understand the burden of disease."]},{"key":"dc:title","label":"Title","values":["Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital"]}]}],"canonical_facts":{"dc:contributor.advisor":["Tooke, Lloyd"],"dc:creator":["Browne, Bradley"],"dc:date.accessioned":["2024-04-04T08:15:03Z"],"dc:date.available":["2024-04-04T08:15:03Z"],"dc:date.issued":["2023"],"dc:description.abstract":["Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, especially in the Western Cape. Objective. This study aims to describe a case series of newborns with iGBS in a tertiary hospital in the Western Cape. Methods. A retrospective folder review was conducted between January 2015 and December 2020. Results. Thirty five cases of invasive GBS disease were included in the study, 51% with earlyonset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups respectively. The median birth weight was 900 g and 1812 g in the LoD and EoD group respectively. Meningits was more common in the LoD group, and pneumonia more common in the EoD group. The overall mortality rate was 23%, and GBS disease accounted for a cumulative 274 days in the intensive care unit. Conclusion. Invasive GBS disease in newborns at GSH carries a high mortality rate with a similar burden of LoD and EoD. More studies of newborn iGBS are needed in the Western Cape and South Africa to better understand the burden of disease."],"dc:identifier.uri":["http://hdl.handle.net/11427/39301"],"dc:publisher.department":["Department of Paediatrics and Child Health"],"dc:subject":["Paediatrics"],"dc:title":["Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Masters","MMed"]},"updated_at":"2026-07-22T22:23:14Z"}