Mycotoxin health risk assessment modelling among maize-subsistence farmers living in Centane, Eastern Cape Province, South Africa
type: CreativeWork
description: Harmful mycotoxins such as fumonisin B (FB), deoxynivalenol (DON), and zearalenone (ZEA), produced by ubiquitous food-borne fungal species, are known to contaminate maize crops from subsistence farming areas in Centane, Eastern Cape Province (EC), South Africa. The daily consumption of home-grown maize in these areas has resulted in FB exposure of five to ten times above the recommended provisional maximum tolerable daily intake (PMTDI) of 2 µg kg-1 body weight day-1 , as set by The Joint FAO/WHO Expert Committee on Food Additives. From a public health perspective, not only can these mycotoxins cause various human diseases but also impact food security. For this purpose, mycotoxin risk assessment among maizesubsistence farmers is critical to ensure evidence-based risk management. Currently, in resources poor settings, a deterministic risk assessment approach remains the easiest and most accessible. This approach, based on epidemiological data, includes using a total mean mycotoxin level (µg kg-1 ) multiplied by the individual total mean dry/raw maize intake in g day-1 divided by body weight (kg) and expressed as a probable daily intake (PDI). The resultant PDI is thereafter compared to the relevant mycotoxin PMTDI to determine the risk. However, this type of assessment remains one-dimensional and can only quantify risk. To address this limitation, the current study was aimed at developing a mycotoxin risk assessment model that not only quantifies the risk of exposure to multi-mycotoxins (FB, DON, and ZEA) but it is also interactive. The new model was based on the Mycotoxin Risk Assessment Model (MYCORAM) that was originally developed for South African commercial maize consumers and referred to as the MYCORAM-II. The overall purpose of the MYCORAM-II is to assess the percentage of maize consumers above the relevant mycotoxins PMTDI. In the current study, a multiphase study design was used to develop and evaluate the model consisting of phase 1) dietary maize intake, …
abstract: Harmful mycotoxins such as fumonisin B (FB), deoxynivalenol (DON), and zearalenone (ZEA), produced by ubiquitous food-borne fungal species, are known to contaminate maize crops from subsistence farming areas in Centane, Eastern Cape Province (EC), South Africa. The daily consumption of home-grown maize in these areas has resulted in FB exposure of five to ten times above the recommended provisional maximum tolerable daily intake (PMTDI) of 2 µg kg-1 body weight day-1 , as set by The Joint FAO/WHO Expert Committee on Food Additives. From a public health perspective, not only can these mycotoxins cause various human diseases but also impact food security. For this purpose, mycotoxin risk assessment among maizesubsistence farmers is critical to ensure evidence-based risk management. Currently, in resources poor settings, a deterministic risk assessment approach remains the easiest and most accessible. This approach, based on epidemiological data, includes using a total mean mycotoxin level (µg kg-1 ) multiplied by the individual total mean dry/raw maize intake in g day-1 divided by body weight (kg) and expressed as a probable daily intake (PDI). The resultant PDI is thereafter compared to the relevant mycotoxin PMTDI to determine the risk. However, this type of assessment remains one-dimensional and can only quantify risk. To address this limitation, the current study was aimed at developing a mycotoxin risk assessment model that not only quantifies the risk of exposure to multi-mycotoxins (FB, DON, and ZEA) but it is also interactive. The new model was based on the Mycotoxin Risk Assessment Model (MYCORAM) that was originally developed for South African commercial maize consumers and referred to as the MYCORAM-II. The overall purpose of the MYCORAM-II is to assess the percentage of maize consumers above the relevant mycotoxins PMTDI. In the current study, a multiphase study design was used to develop and evaluate the model consisting of phase 1) dietary maize intake, …
author: Burger, Hester-Mari
keywords: Environmental Health
date published: 2022
date modified: 2026-07-22T22:23:09Z
provider: University of Cape Town
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Department of Public Health and Family Medicine

PropertyValue
property ID: Handle
value: http://hdl.handle.net/11427/37411