{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/35515"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/35515","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study","abstract":"Background: Chemotherapy-induced alopecia (CIA) is a common side-effect of breast cancer treatment. Scalp cooling is reported to reduce CIA; however, it is unknown whether the efficacy is influenced by hair curvature. Methods: This 20-month randomized controlled trial recruited females, (18-65 years) with breast cancer to receive chemotherapy (Adriamycin or Epirubicin and Cyclophosphamide followed by Paclitaxel) with or without scalp cooling. The main outcomes were percentage alopecia (Severity ALopecia Tool scored by 3 dermatologists) in straight versus curly hair and treatment retention rates. Results: Forty-eight patients (24 per group) were randomized; 4 in each group withdrew before study visit1 and photographs of 3 in the cooling group could not be found for severity assessment. Thus 77% constituted the intention to treat population (17 cooling versus 20 control). Agreement on alopecia severity was good overall (ICC=0,94; 95% CI: 0.85 - 0.97) and at 6 of 7 time points. Overall, cooling significantly reduced CIA, relative to no cooling (58.15 ± 28.46 versus 37.29 ± 20.52; p:0.0167), however, percentage alopecia was cosmetically significant. There was no difference in CIA between cooling participants with straight (8) versus curly hair (9), (p:0.0740). The number of patients completing the various cycles of chemotherapy, declined from 77.1% at cycle 1 to 18.8% at cycle 7 for the whole study; from 100% each to 17.6% and 30% for cooling and control groups, respectively (p:0.451). Conclusions: This small study suggests that hair curvature has no significant impact on the efficacy of scalp cooling to reduce CIA, however this requires confirmation.","abstract_html":"Background: Chemotherapy-induced alopecia (CIA) is a common side-effect of breast cancer treatment. Scalp cooling is reported to reduce CIA; however, it is unknown whether the efficacy is influenced by hair curvature. Methods: This 20-month randomized controlled trial recruited females, (18-65 years) with breast cancer to receive chemotherapy (Adriamycin or Epirubicin and Cyclophosphamide followed by Paclitaxel) with or without scalp cooling. The main outcomes were percentage alopecia (Severity ALopecia Tool scored by 3 dermatologists) in straight versus curly hair and treatment retention rates. Results: Forty-eight patients (24 per group) were randomized; 4 in each group withdrew before study visit1 and photographs of 3 in the cooling group could not be found for severity assessment. Thus 77% constituted the intention to treat population (17 cooling versus 20 control). Agreement on alopecia severity was good overall (ICC=0,94; 95% CI: 0.85 - 0.97) and at 6 of 7 time points. Overall, cooling significantly reduced CIA, relative to no cooling (58.15 ± 28.46 versus 37.29 ± 20.52; p:0.0167), however, percentage alopecia was cosmetically significant. There was no difference in CIA between cooling participants with straight (8) versus curly hair (9), (p:0.0740). The number of patients completing the various cycles of chemotherapy, declined from 77.1% at cycle 1 to 18.8% at cycle 7 for the whole study; from 100% each to 17.6% and 30% for cooling and control groups, respectively (p:0.451). Conclusions: This small study suggests that hair curvature has no significant impact on the efficacy of scalp cooling to reduce CIA, however this requires confirmation.","abstract_has_math":false,"creators":["Obuseng, Odirile"],"institution":"Division of Radiology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Khumalo, Nonhlanhla P","Naiker, Thurandrie","Thebe, Tselane"],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021","date_published":"2021","updated_at":"2026-07-22T22:22:47Z","subjects":["radiology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/35515","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Khumalo, Nonhlanhla P","Naiker, Thurandrie","Thebe, Tselane"]},{"key":"dc:creator","label":"Author","values":["Obuseng, Odirile"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2022-01-18T10:10:14Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2022-01-18T10:10:14Z"]},{"key":"dc:date.issued","label":"Date","values":["2021"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Radiology"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters","MMed"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["radiology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/35515"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Chemotherapy-induced alopecia (CIA) is a common side-effect of breast cancer treatment. Scalp cooling is reported to reduce CIA; however, it is unknown whether the efficacy is influenced by hair curvature. Methods: This 20-month randomized controlled trial recruited females, (18-65 years) with breast cancer to receive chemotherapy (Adriamycin or Epirubicin and Cyclophosphamide followed by Paclitaxel) with or without scalp cooling. The main outcomes were percentage alopecia (Severity ALopecia Tool scored by 3 dermatologists) in straight versus curly hair and treatment retention rates. Results: Forty-eight patients (24 per group) were randomized; 4 in each group withdrew before study visit1 and photographs of 3 in the cooling group could not be found for severity assessment. Thus 77% constituted the intention to treat population (17 cooling versus 20 control). Agreement on alopecia severity was good overall (ICC=0,94; 95% CI: 0.85 - 0.97) and at 6 of 7 time points. Overall, cooling significantly reduced CIA, relative to no cooling (58.15 ± 28.46 versus 37.29 ± 20.52; p:0.0167), however, percentage alopecia was cosmetically significant. There was no difference in CIA between cooling participants with straight (8) versus curly hair (9), (p:0.0740). The number of patients completing the various cycles of chemotherapy, declined from 77.1% at cycle 1 to 18.8% at cycle 7 for the whole study; from 100% each to 17.6% and 30% for cooling and control groups, respectively (p:0.451). Conclusions: This small study suggests that hair curvature has no significant impact on the efficacy of scalp cooling to reduce CIA, however this requires confirmation."]},{"key":"dc:title","label":"Title","values":["Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study"]}]}],"canonical_facts":{"dc:contributor.advisor":["Khumalo, Nonhlanhla P","Naiker, Thurandrie","Thebe, Tselane"],"dc:creator":["Obuseng, Odirile"],"dc:date.accessioned":["2022-01-18T10:10:14Z"],"dc:date.available":["2022-01-18T10:10:14Z"],"dc:date.issued":["2021"],"dc:description.abstract":["Background: Chemotherapy-induced alopecia (CIA) is a common side-effect of breast cancer treatment. Scalp cooling is reported to reduce CIA; however, it is unknown whether the efficacy is influenced by hair curvature. Methods: This 20-month randomized controlled trial recruited females, (18-65 years) with breast cancer to receive chemotherapy (Adriamycin or Epirubicin and Cyclophosphamide followed by Paclitaxel) with or without scalp cooling. The main outcomes were percentage alopecia (Severity ALopecia Tool scored by 3 dermatologists) in straight versus curly hair and treatment retention rates. Results: Forty-eight patients (24 per group) were randomized; 4 in each group withdrew before study visit1 and photographs of 3 in the cooling group could not be found for severity assessment. Thus 77% constituted the intention to treat population (17 cooling versus 20 control). Agreement on alopecia severity was good overall (ICC=0,94; 95% CI: 0.85 - 0.97) and at 6 of 7 time points. Overall, cooling significantly reduced CIA, relative to no cooling (58.15 ± 28.46 versus 37.29 ± 20.52; p:0.0167), however, percentage alopecia was cosmetically significant. There was no difference in CIA between cooling participants with straight (8) versus curly hair (9), (p:0.0740). The number of patients completing the various cycles of chemotherapy, declined from 77.1% at cycle 1 to 18.8% at cycle 7 for the whole study; from 100% each to 17.6% and 30% for cooling and control groups, respectively (p:0.451). Conclusions: This small study suggests that hair curvature has no significant impact on the efficacy of scalp cooling to reduce CIA, however this requires confirmation."],"dc:identifier.uri":["http://hdl.handle.net/11427/35515"],"dc:publisher.department":["Division of Radiology"],"dc:subject":["radiology"],"dc:title":["Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters","MMed"]},"updated_at":"2026-07-22T22:22:47Z"}