{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3501"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3501","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.","abstract":"The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke.","abstract_html":"The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke.","abstract_has_math":false,"creators":["Allie, Sameera"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Combrinck, Marc"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-22T22:23:26Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3501","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Combrinck, Marc"]},{"key":"dc:creator","label":"Author","values":["Allie, Sameera"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-29T09:38:54Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-29T09:38:54Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3501"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke."]},{"key":"dc:title","label":"Title","values":["The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke."]}]}],"canonical_facts":{"dc:contributor.advisor":["Combrinck, Marc"],"dc:creator":["Allie, Sameera"],"dc:date.accessioned":["2014-07-29T09:38:54Z"],"dc:date.available":["2014-07-29T09:38:54Z"],"dc:date.issued":["2013"],"dc:description":["Includes abstract.","Includes bibliographical references."],"dc:description.abstract":["The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke."],"dc:identifier.uri":["http://hdl.handle.net/11427/3501"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke."],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:26Z"}