{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3473"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3473","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning","abstract":"Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial infarction. This protective phenomenon that lessens myocardial infarction can be mimicked by the cytokine tumor necrosis factor alpha (TNFα) but the signalling pathways involved still remain unclear.","abstract_html":"Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial infarction. This protective phenomenon that lessens myocardial infarction can be mimicked by the cytokine tumor necrosis factor alpha (TNFα) but the signalling pathways involved still remain unclear.","abstract_has_math":false,"creators":["Suleman, Naushaad"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Lecour, S","Smith, R"],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-24T01:34:03Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3473","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Lecour, S","Smith, R"]},{"key":"dc:creator","label":"Author","values":["Suleman, Naushaad"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-29T09:11:10Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-29T09:11:10Z"]},{"key":"dc:date.issued","label":"Date","values":["2006"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3473"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 150-177)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial infarction. This protective phenomenon that lessens myocardial infarction can be mimicked by the cytokine tumor necrosis factor alpha (TNFα) but the signalling pathways involved still remain unclear."]},{"key":"dc:title","label":"Title","values":["The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning"]}]}],"canonical_facts":{"dc:contributor.advisor":["Lecour, S","Smith, R"],"dc:creator":["Suleman, Naushaad"],"dc:date.accessioned":["2014-07-29T09:11:10Z"],"dc:date.available":["2014-07-29T09:11:10Z"],"dc:date.issued":["2006"],"dc:description":["Includes bibliographical references (leaves 150-177)."],"dc:description.abstract":["Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial infarction. This protective phenomenon that lessens myocardial infarction can be mimicked by the cytokine tumor necrosis factor alpha (TNFα) but the signalling pathways involved still remain unclear."],"dc:identifier.uri":["http://hdl.handle.net/11427/3473"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-24T01:34:03Z"}