{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3453"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3453","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Approaches to the diagnosis of smear-negative and sputum-scarce TB in South Africa","abstract":"In South Africa, an HIV-endemic setting, the burden of smear-negative (SN) and sputum-scarce (SS) TB is a major public health catastrophe. Diagnostic delay or failure is a key bottleneck. We hypothesised that i) assisted sputum smpling using sputum induction (SI), and ii) the use of the newer diagnostic tools (Xpert MTB/RIF and urine LAM strip), could improve diagnosis of SN or SSTB and impact clinical care. We investigated the accuracy and impact of these approaches at different levels in the health-system.","abstract_html":"In South Africa, an HIV-endemic setting, the burden of smear-negative (SN) and sputum-scarce (SS) TB is a major public health catastrophe. Diagnostic delay or failure is a key bottleneck. We hypothesised that i) assisted sputum smpling using sputum induction (SI), and ii) the use of the newer diagnostic tools (Xpert MTB/RIF and urine LAM strip), could improve diagnosis of SN or SSTB and impact clinical care. We investigated the accuracy and impact of these approaches at different levels in the health-system.","abstract_has_math":false,"creators":["Peter, Jonathan G"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Dheda, Keertan"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-22T22:22:58Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3453","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Dheda, Keertan"]},{"key":"dc:creator","label":"Author","values":["Peter, Jonathan G"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-29T09:09:39Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-29T09:09:39Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3453"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["In South Africa, an HIV-endemic setting, the burden of smear-negative (SN) and sputum-scarce (SS) TB is a major public health catastrophe. Diagnostic delay or failure is a key bottleneck. We hypothesised that i) assisted sputum smpling using sputum induction (SI), and ii) the use of the newer diagnostic tools (Xpert MTB/RIF and urine LAM strip), could improve diagnosis of SN or SSTB and impact clinical care. We investigated the accuracy and impact of these approaches at different levels in the health-system."]},{"key":"dc:title","label":"Title","values":["Approaches to the diagnosis of smear-negative and sputum-scarce TB in South Africa"]}]}],"canonical_facts":{"dc:contributor.advisor":["Dheda, Keertan"],"dc:creator":["Peter, Jonathan G"],"dc:date.accessioned":["2014-07-29T09:09:39Z"],"dc:date.available":["2014-07-29T09:09:39Z"],"dc:date.issued":["2013"],"dc:description":["Includes abstract.","Includes bibliographical references."],"dc:description.abstract":["In South Africa, an HIV-endemic setting, the burden of smear-negative (SN) and sputum-scarce (SS) TB is a major public health catastrophe. Diagnostic delay or failure is a key bottleneck. We hypothesised that i) assisted sputum smpling using sputum induction (SI), and ii) the use of the newer diagnostic tools (Xpert MTB/RIF and urine LAM strip), could improve diagnosis of SN or SSTB and impact clinical care. We investigated the accuracy and impact of these approaches at different levels in the health-system."],"dc:identifier.uri":["http://hdl.handle.net/11427/3453"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Approaches to the diagnosis of smear-negative and sputum-scarce TB in South Africa"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:22:58Z"}