Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans

Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and neurohormonal mechanisms that include the action of leptin. As there appear to be no focussed studies that have looked at the association of the LEP gene with kidney disease phenotypes or cardiovascular disease markers like hypertension, the metabolic syndrome and obesity, and especially so in native black Africans, this study sought to establish an association between the obesity gene (LEP) and kidney disease phenotypes (independent of diabetes and hypertension) in a homogenous black African population.

Grantor dc:publisher.institution

Department of Medicine

Year dc:date.issued

2008

Author dc:creator

• Okpechi, Ikechi Gareth

Advisors dc:contributor.advisor

• Meissner, P
• Rayner, B L
• Ramesar, R
• Pascoe, M D

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3446

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3446