{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3408"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3408","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration","abstract":"Current replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre vessels (<;6 mm) due to graft thrombosis and mechanical mismatch between artery and graft. Tissue engineering offers a promising approach to overcome these shortcomings. With porosity as a fundamental prerequisite for tissue ingrowth, several techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the change in mechanical and physical properties of the scaffolds associated with hydrolytic in vitro degradation.","abstract_html":"Current replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre vessels (&lt;;6 mm) due to graft thrombosis and mechanical mismatch between artery and graft. Tissue engineering offers a promising approach to overcome these shortcomings. With porosity as a fundamental prerequisite for tissue ingrowth, several techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the change in mechanical and physical properties of the scaffolds associated with hydrolytic in vitro degradation.","abstract_has_math":false,"creators":["Khatib, Rodaina Omar"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Franz, Thomas","Krynauw, Hugo","Bezuidenhout, Deon"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-22T22:23:34Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3408","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Franz, Thomas","Krynauw, Hugo","Bezuidenhout, Deon"]},{"key":"dc:creator","label":"Author","values":["Khatib, Rodaina Omar"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-29T09:04:08Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-29T09:04:08Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3408"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["Current replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre vessels (<;6 mm) due to graft thrombosis and mechanical mismatch between artery and graft. Tissue engineering offers a promising approach to overcome these shortcomings. With porosity as a fundamental prerequisite for tissue ingrowth, several techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the change in mechanical and physical properties of the scaffolds associated with hydrolytic in vitro degradation."]},{"key":"dc:title","label":"Title","values":["Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration"]}]}],"canonical_facts":{"dc:contributor.advisor":["Franz, Thomas","Krynauw, Hugo","Bezuidenhout, Deon"],"dc:creator":["Khatib, Rodaina Omar"],"dc:date.accessioned":["2014-07-29T09:04:08Z"],"dc:date.available":["2014-07-29T09:04:08Z"],"dc:date.issued":["2013"],"dc:description":["Includes abstract.","Includes bibliographical references."],"dc:description.abstract":["Current replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre vessels (<;6 mm) due to graft thrombosis and mechanical mismatch between artery and graft. Tissue engineering offers a promising approach to overcome these shortcomings. With porosity as a fundamental prerequisite for tissue ingrowth, several techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the change in mechanical and physical properties of the scaffolds associated with hydrolytic in vitro degradation."],"dc:identifier.uri":["http://hdl.handle.net/11427/3408"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:34Z"}