{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3396"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3396","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Phytosterol-enriched margarine substitution in the management of familial hypercholesterolaemia","abstract":"The primary objective was to substitute phytosterol and regula margarine into the diets of familial hypercholesterolaemia (FH) patients and to investigate whether the phytosterol containing margarine had a cholesterol lowering effect. Another objective was to investigate immune responses to phytosterols. A randomized double-blind cross-over study in which subjects with FH consumed 20g of regular or phytosterol margarine for a period of 6 weeks on each margarine, after which a washout period of 4 weeks was followed. There were 5 visits in total, visit 1 being the collection of baseline data, visit 2 the randomisation to either of the regular of phytosterol margarine periods, visit 3 for the cross-ver to the alternative margarine form, visit 4 marked the onset of washout period and visit 5, was the last evaluation visit. Margarine use was in addition to current, albeit limite, pharmacological treatment with statins.","abstract_html":"The primary objective was to substitute phytosterol and regula margarine into the diets of familial hypercholesterolaemia (FH) patients and to investigate whether the phytosterol containing margarine had a cholesterol lowering effect. Another objective was to investigate immune responses to phytosterols. A randomized double-blind cross-over study in which subjects with FH consumed 20g of regular or phytosterol margarine for a period of 6 weeks on each margarine, after which a washout period of 4 weeks was followed. There were 5 visits in total, visit 1 being the collection of baseline data, visit 2 the randomisation to either of the regular of phytosterol margarine periods, visit 3 for the cross-ver to the alternative margarine form, visit 4 marked the onset of washout period and visit 5, was the last evaluation visit. Margarine use was in addition to current, albeit limite, pharmacological treatment with statins.","abstract_has_math":false,"creators":["Hamdulay, Zarina"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Marais, David","Visser, Marianne"],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002","date_published":"2002","updated_at":"2026-07-22T22:23:02Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3396","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Marais, David","Visser, Marianne"]},{"key":"dc:creator","label":"Author","values":["Hamdulay, Zarina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-29T09:03:46Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-29T09:03:46Z"]},{"key":"dc:date.issued","label":"Date","values":["2002"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3396"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["The primary objective was to substitute phytosterol and regula margarine into the diets of familial hypercholesterolaemia (FH) patients and to investigate whether the phytosterol containing margarine had a cholesterol lowering effect. Another objective was to investigate immune responses to phytosterols. A randomized double-blind cross-over study in which subjects with FH consumed 20g of regular or phytosterol margarine for a period of 6 weeks on each margarine, after which a washout period of 4 weeks was followed. There were 5 visits in total, visit 1 being the collection of baseline data, visit 2 the randomisation to either of the regular of phytosterol margarine periods, visit 3 for the cross-ver to the alternative margarine form, visit 4 marked the onset of washout period and visit 5, was the last evaluation visit. Margarine use was in addition to current, albeit limite, pharmacological treatment with statins."]},{"key":"dc:title","label":"Title","values":["Phytosterol-enriched margarine substitution in the management of familial hypercholesterolaemia"]}]}],"canonical_facts":{"dc:contributor.advisor":["Marais, David","Visser, Marianne"],"dc:creator":["Hamdulay, Zarina"],"dc:date.accessioned":["2014-07-29T09:03:46Z"],"dc:date.available":["2014-07-29T09:03:46Z"],"dc:date.issued":["2002"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["The primary objective was to substitute phytosterol and regula margarine into the diets of familial hypercholesterolaemia (FH) patients and to investigate whether the phytosterol containing margarine had a cholesterol lowering effect. Another objective was to investigate immune responses to phytosterols. A randomized double-blind cross-over study in which subjects with FH consumed 20g of regular or phytosterol margarine for a period of 6 weeks on each margarine, after which a washout period of 4 weeks was followed. There were 5 visits in total, visit 1 being the collection of baseline data, visit 2 the randomisation to either of the regular of phytosterol margarine periods, visit 3 for the cross-ver to the alternative margarine form, visit 4 marked the onset of washout period and visit 5, was the last evaluation visit. Margarine use was in addition to current, albeit limite, pharmacological treatment with statins."],"dc:identifier.uri":["http://hdl.handle.net/11427/3396"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Phytosterol-enriched margarine substitution in the management of familial hypercholesterolaemia"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:02Z"}