{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/33903"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/33903","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa","abstract":"Background: Histological sampling of pulmonary lesions is important in diagnosis of lung carcinoma and affects subsequent decisions on specific management. Transthoracic CT-guided lung biopsy is considered an effective option to obtain tissue with low rates of complications, with pneumothorax being the most common. Objectives: To determine the pneumothorax rate of transthoracic CT-guided lung biopsies of focal lung lesions at Groote Schuur Hospital, and assess how procedural, patient and lesion factors influence these results. Methods: A retrospective review of 237 CT-guided lung biopsies performed over a 24-month period. Patient's CT, biopsy reports and post-procedure x-rays were reviewed. The relationship between pneumothorax rates and categorical demographic and clinical variables was analysed with Cochran's trend test. Mann-Whitney U tests were used to assess differences in continuous variables. Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary Centre in Cape Town, South Africa. Results: Pneumothorax occurred in 43 (18.1%) of the 237 biopsies. A chest drain was required in 7 of 43 pneumothoraces (16%; 3% overall). Risk factors that were significantly associated with pneumothorax rate include pleural-lesion distance (p<0.001), smaller lesion size (p=0.002), smaller needle gauge (p=0.012) and perilesional emphysema (p=0.011). Patient age, sex, position, lesion location and level of experience of the performing radiologist had no significant influence on the pneumothorax rate. Conclusion: Our post-procedure pneumothorax rate is within the acceptable range when compared to other institutions. Pleural-lesion distance, lesion size, smaller needle gauge and presence of perilesional emphysema were the most significant risk factors influencing pneumothorax rate. Knowledge of these findings may be applicable in pre-procedure planning to reduce complications and useful to local referring clinicians and patients.","abstract_html":"Background: Histological sampling of pulmonary lesions is important in diagnosis of lung carcinoma and affects subsequent decisions on specific management. Transthoracic CT-guided lung biopsy is considered an effective option to obtain tissue with low rates of complications, with pneumothorax being the most common. Objectives: To determine the pneumothorax rate of transthoracic CT-guided lung biopsies of focal lung lesions at Groote Schuur Hospital, and assess how procedural, patient and lesion factors influence these results. Methods: A retrospective review of 237 CT-guided lung biopsies performed over a 24-month period. Patient&#x27;s CT, biopsy reports and post-procedure x-rays were reviewed. The relationship between pneumothorax rates and categorical demographic and clinical variables was analysed with Cochran&#x27;s trend test. Mann-Whitney U tests were used to assess differences in continuous variables. Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary Centre in Cape Town, South Africa. Results: Pneumothorax occurred in 43 (18.1%) of the 237 biopsies. A chest drain was required in 7 of 43 pneumothoraces (16%; 3% overall). Risk factors that were significantly associated with pneumothorax rate include pleural-lesion distance (p&lt;0.001), smaller lesion size (p=0.002), smaller needle gauge (p=0.012) and perilesional emphysema (p=0.011). Patient age, sex, position, lesion location and level of experience of the performing radiologist had no significant influence on the pneumothorax rate. Conclusion: Our post-procedure pneumothorax rate is within the acceptable range when compared to other institutions. Pleural-lesion distance, lesion size, smaller needle gauge and presence of perilesional emphysema were the most significant risk factors influencing pneumothorax rate. Knowledge of these findings may be applicable in pre-procedure planning to reduce complications and useful to local referring clinicians and patients.","abstract_has_math":false,"creators":["Richards-Edwards, William H"],"institution":"Division of Radiology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Said-Hartley, Qonita"],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020","date_published":"2020","updated_at":"2026-07-22T22:23:39Z","subjects":["Radiodiagnosis"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/33903","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Said-Hartley, Qonita"]},{"key":"dc:creator","label":"Author","values":["Richards-Edwards, William H"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2021-09-15T09:51:43Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2021-09-15T09:51:43Z"]},{"key":"dc:date.issued","label":"Date","values":["2020"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Radiology"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters","MMed"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Radiodiagnosis"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/33903"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Histological sampling of pulmonary lesions is important in diagnosis of lung carcinoma and affects subsequent decisions on specific management. Transthoracic CT-guided lung biopsy is considered an effective option to obtain tissue with low rates of complications, with pneumothorax being the most common. Objectives: To determine the pneumothorax rate of transthoracic CT-guided lung biopsies of focal lung lesions at Groote Schuur Hospital, and assess how procedural, patient and lesion factors influence these results. Methods: A retrospective review of 237 CT-guided lung biopsies performed over a 24-month period. Patient's CT, biopsy reports and post-procedure x-rays were reviewed. The relationship between pneumothorax rates and categorical demographic and clinical variables was analysed with Cochran's trend test. Mann-Whitney U tests were used to assess differences in continuous variables. Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary Centre in Cape Town, South Africa. Results: Pneumothorax occurred in 43 (18.1%) of the 237 biopsies. A chest drain was required in 7 of 43 pneumothoraces (16%; 3% overall). Risk factors that were significantly associated with pneumothorax rate include pleural-lesion distance (p<0.001), smaller lesion size (p=0.002), smaller needle gauge (p=0.012) and perilesional emphysema (p=0.011). Patient age, sex, position, lesion location and level of experience of the performing radiologist had no significant influence on the pneumothorax rate. Conclusion: Our post-procedure pneumothorax rate is within the acceptable range when compared to other institutions. Pleural-lesion distance, lesion size, smaller needle gauge and presence of perilesional emphysema were the most significant risk factors influencing pneumothorax rate. Knowledge of these findings may be applicable in pre-procedure planning to reduce complications and useful to local referring clinicians and patients."]},{"key":"dc:title","label":"Title","values":["Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa"]}]}],"canonical_facts":{"dc:contributor.advisor":["Said-Hartley, Qonita"],"dc:creator":["Richards-Edwards, William H"],"dc:date.accessioned":["2021-09-15T09:51:43Z"],"dc:date.available":["2021-09-15T09:51:43Z"],"dc:date.issued":["2020"],"dc:description.abstract":["Background: Histological sampling of pulmonary lesions is important in diagnosis of lung carcinoma and affects subsequent decisions on specific management. Transthoracic CT-guided lung biopsy is considered an effective option to obtain tissue with low rates of complications, with pneumothorax being the most common. Objectives: To determine the pneumothorax rate of transthoracic CT-guided lung biopsies of focal lung lesions at Groote Schuur Hospital, and assess how procedural, patient and lesion factors influence these results. Methods: A retrospective review of 237 CT-guided lung biopsies performed over a 24-month period. Patient's CT, biopsy reports and post-procedure x-rays were reviewed. The relationship between pneumothorax rates and categorical demographic and clinical variables was analysed with Cochran's trend test. Mann-Whitney U tests were used to assess differences in continuous variables. Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary Centre in Cape Town, South Africa. Results: Pneumothorax occurred in 43 (18.1%) of the 237 biopsies. A chest drain was required in 7 of 43 pneumothoraces (16%; 3% overall). Risk factors that were significantly associated with pneumothorax rate include pleural-lesion distance (p<0.001), smaller lesion size (p=0.002), smaller needle gauge (p=0.012) and perilesional emphysema (p=0.011). Patient age, sex, position, lesion location and level of experience of the performing radiologist had no significant influence on the pneumothorax rate. Conclusion: Our post-procedure pneumothorax rate is within the acceptable range when compared to other institutions. Pleural-lesion distance, lesion size, smaller needle gauge and presence of perilesional emphysema were the most significant risk factors influencing pneumothorax rate. Knowledge of these findings may be applicable in pre-procedure planning to reduce complications and useful to local referring clinicians and patients."],"dc:identifier.uri":["http://hdl.handle.net/11427/33903"],"dc:publisher.department":["Division of Radiology"],"dc:subject":["Radiodiagnosis"],"dc:title":["Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters","MMed"]},"updated_at":"2026-07-22T22:23:39Z"}