Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation

Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk

Grantor dc:publisher.institution

Department of Medicine

Year dc:date.issued

2012

Author dc:creator

• Centner, Chad

Advisors dc:contributor.advisor

• Heckmann, Jeannine
• Dandara, Collet

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3370

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3370