{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3298"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3298","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The effect of quinoline anti-malarial drugs on the endolysosomal and secretory pathways of plasmodium falciparum strain 3D7, dictyostelium discoideum and mammalian A549 cells","abstract":"The precise mechanisms of action of the quinoline anti-malarial drugs are uncertain, although they have been found to influence endocytosis, vesicular processing and secretion in malarial parasites and mammalian cells. In this study, the effects of chloroquine, amadiaquine, halofantrine, mefloquine and quinine on the endolysosomal systems in Plasmodium falciparum 3D7, Dictyostelium discoideum and A549 pulmonary cancer cells were examined.","abstract_html":"The precise mechanisms of action of the quinoline anti-malarial drugs are uncertain, although they have been found to influence endocytosis, vesicular processing and secretion in malarial parasites and mammalian cells. In this study, the effects of chloroquine, amadiaquine, halofantrine, mefloquine and quinine on the endolysosomal systems in Plasmodium falciparum 3D7, Dictyostelium discoideum and A549 pulmonary cancer cells were examined.","abstract_has_math":false,"creators":["Roberts, Lindi"],"institution":"Division of Clinical Pharmacology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Hoppe, Heinrich C"],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007","date_published":"2007","updated_at":"2026-07-22T22:22:42Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3298","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Hoppe, Heinrich C"]},{"key":"dc:creator","label":"Author","values":["Roberts, Lindi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-28T18:20:16Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-28T18:20:16Z"]},{"key":"dc:date.issued","label":"Date","values":["2007"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Clinical Pharmacology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3298"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 92-109)."]},{"key":"dc:description.abstract","label":"Abstract","values":["The precise mechanisms of action of the quinoline anti-malarial drugs are uncertain, although they have been found to influence endocytosis, vesicular processing and secretion in malarial parasites and mammalian cells. In this study, the effects of chloroquine, amadiaquine, halofantrine, mefloquine and quinine on the endolysosomal systems in Plasmodium falciparum 3D7, Dictyostelium discoideum and A549 pulmonary cancer cells were examined."]},{"key":"dc:title","label":"Title","values":["The effect of quinoline anti-malarial drugs on the endolysosomal and secretory pathways of plasmodium falciparum strain 3D7, dictyostelium discoideum and mammalian A549 cells"]}]}],"canonical_facts":{"dc:contributor.advisor":["Hoppe, Heinrich C"],"dc:creator":["Roberts, Lindi"],"dc:date.accessioned":["2014-07-28T18:20:16Z"],"dc:date.available":["2014-07-28T18:20:16Z"],"dc:date.issued":["2007"],"dc:description":["Includes bibliographical references (leaves 92-109)."],"dc:description.abstract":["The precise mechanisms of action of the quinoline anti-malarial drugs are uncertain, although they have been found to influence endocytosis, vesicular processing and secretion in malarial parasites and mammalian cells. In this study, the effects of chloroquine, amadiaquine, halofantrine, mefloquine and quinine on the endolysosomal systems in Plasmodium falciparum 3D7, Dictyostelium discoideum and A549 pulmonary cancer cells were examined."],"dc:identifier.uri":["http://hdl.handle.net/11427/3298"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Clinical Pharmacology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The effect of quinoline anti-malarial drugs on the endolysosomal and secretory pathways of plasmodium falciparum strain 3D7, dictyostelium discoideum and mammalian A549 cells"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:22:42Z"}