{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3270"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3270","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors","abstract":"This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6).","abstract_html":"This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6).","abstract_has_math":false,"creators":["Mokone, Gaonyadiwe George"],"institution":"Department of Human Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Collins, Malcolm","Schwellnus, Martin"],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-22T22:23:01Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3270","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Collins, Malcolm","Schwellnus, Martin"]},{"key":"dc:creator","label":"Author","values":["Mokone, Gaonyadiwe George"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-28T18:17:33Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-28T18:17:33Z"]},{"key":"dc:date.issued","label":"Date","values":["2006"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Human Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3270"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6)."]},{"key":"dc:title","label":"Title","values":["Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors"]}]}],"canonical_facts":{"dc:contributor.advisor":["Collins, Malcolm","Schwellnus, Martin"],"dc:creator":["Mokone, Gaonyadiwe George"],"dc:date.accessioned":["2014-07-28T18:17:33Z"],"dc:date.available":["2014-07-28T18:17:33Z"],"dc:date.issued":["2006"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6)."],"dc:identifier.uri":["http://hdl.handle.net/11427/3270"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Human Biology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:01Z"}