The expression and functional analysis of neurite outgrowth inhibitors in the nervous system of Xenopus laevis

Generally, the factors contributing to success or failure of axon regeneration lie in the intrinsic properties of the injured neurons, as well as the surrounding microenvironment of the transected axon. Mammalian neurons may lack the intrinsic ability to survive after trauma, or to re-express genes required for axonal regrowth. Moreover, several proteins inhibitory to neurite growth, such as Tenascin-R (TN-R) and Nogo-A, have been identified in mammals. These proteins are associated with oligodendrocytes and myelin and are considered major inhibitory components of the CNS environment.

Grantor dc:publisher.institution

Department of Human Biology

Year dc:date.issued

2007

Author dc:creator

• Hsu, Nai-Jen

Advisor dc:contributor.advisor

• Lang, Dirk M

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3249

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3249