Dysnatremia and the endocrine regulation of fluid balance during exercise

The aim of this thesis is to evaluate both abnormal and normal fluid balance during exercise. The central theme permeating all investigations is an underlying desire to understand exercise-associated hyponatremia. This thesis reflects a journey of scientific investigation primarily launched by outcomes from the 1st International Consensus Development Conference on Exercise-Associated Hyponatremia. Each individual investigation directly follows from the results of the previous investigation. Hence, the journey towards a greater understanding of exercise-associated hyponatremia went full circle and ultimately encompassed the spectrum of fluid regulation and dysregulation during exercise. This thesis begins with a brief overview of the literatur which services to intertwine previous knowledge with new knowledge gained from each successive study. A review of the literature on exercise-associated hyponatremia opens the first chapter and lays the foundation for the follwoing eight investigations. This thesis closes with a final summary of the literature which defends fluid balance physiology as the ultimate guide for developing more "physiologically appropriate" fluid replacement strategies. More specifically, the first two chapters document the abnormal regulation of serum sodium concentration during exercise.

Grantor dc:publisher.institution

Department of Human Biology

Year dc:date.issued

2007

Author dc:creator

• Hew-Butler, Tamara

Advisors dc:contributor.advisor

• Noakes, Tim
• Verbalis, Joseph G

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3246

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3246