{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/32056"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/32056","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Studies on the degradation of haemoglobin","abstract":"The chemical relationship which exists between haemoglobin and bile pigments was first established in 1933, when, after monumental studies covering a period of 24 years, Hans Fischer and his colleagues succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the fundamental tetrapyrrolic structure which is common to both haem and bilirubin. Prior to this, in vivo experiments on dogs performed by Mann, Sheard, Bollman and Blades showed that haemoglobin, injected into the arterial blood of the spleen or bone-marrow, produced a rise in the bilirubin content of the venous blood. Haematin was also evident in both arterial and venous blood.","abstract_html":"The chemical relationship which exists between haemoglobin and bile pigments was first established in 1933, when, after monumental studies covering a period of 24 years, Hans Fischer and his colleagues succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the fundamental tetrapyrrolic structure which is common to both haem and bilirubin. Prior to this, in vivo experiments on dogs performed by Mann, Sheard, Bollman and Blades showed that haemoglobin, injected into the arterial blood of the spleen or bone-marrow, produced a rise in the bilirubin content of the venous blood. Haematin was also evident in both arterial and venous blood.","abstract_has_math":false,"creators":["Green, Margaret"],"institution":"Division of Medical Biochemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Kench, J E"],"committee_chairs":[],"committee_members":[],"year":1966,"date_issued":"1966","date_published":"1966","updated_at":"2026-07-22T22:22:37Z","subjects":["Medical Biochemistry","Hemoglobins"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/32056","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Kench, J E"]},{"key":"dc:creator","label":"Author","values":["Green, Margaret"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-06-10T08:26:37Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-06-10T08:26:37Z"]},{"key":"dc:date.issued","label":"Date","values":["1966"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Medical Biochemistry"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Medical Biochemistry","Hemoglobins"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/32056"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The chemical relationship which exists between haemoglobin and bile pigments was first established in 1933, when, after monumental studies covering a period of 24 years, Hans Fischer and his colleagues succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the fundamental tetrapyrrolic structure which is common to both haem and bilirubin. Prior to this, in vivo experiments on dogs performed by Mann, Sheard, Bollman and Blades showed that haemoglobin, injected into the arterial blood of the spleen or bone-marrow, produced a rise in the bilirubin content of the venous blood. Haematin was also evident in both arterial and venous blood."]},{"key":"dc:title","label":"Title","values":["Studies on the degradation of haemoglobin"]}]}],"canonical_facts":{"dc:contributor.advisor":["Kench, J E"],"dc:creator":["Green, Margaret"],"dc:date.accessioned":["2020-06-10T08:26:37Z"],"dc:date.available":["2020-06-10T08:26:37Z"],"dc:date.issued":["1966"],"dc:description.abstract":["The chemical relationship which exists between haemoglobin and bile pigments was first established in 1933, when, after monumental studies covering a period of 24 years, Hans Fischer and his colleagues succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the fundamental tetrapyrrolic structure which is common to both haem and bilirubin. Prior to this, in vivo experiments on dogs performed by Mann, Sheard, Bollman and Blades showed that haemoglobin, injected into the arterial blood of the spleen or bone-marrow, produced a rise in the bilirubin content of the venous blood. Haematin was also evident in both arterial and venous blood."],"dc:identifier.uri":["http://hdl.handle.net/11427/32056"],"dc:publisher.department":["Division of Medical Biochemistry"],"dc:subject":["Medical Biochemistry","Hemoglobins"],"dc:title":["Studies on the degradation of haemoglobin"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"]},"updated_at":"2026-07-22T22:22:37Z"}