{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3203"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3203","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development","abstract":"Induction of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) and pulmonary neuroendocrine tumors (NETs), which are neoplasms of neural origin, are molecularly different based on their expression of regulatory genes and that exposure to extrinsic factors will alter their growth potential. Using reverse-transcription polymerase chain reaction (RT-PCR) analysis, the present study compared the expression of about 50 regulatory genes that are expressed at early stages of neurogenesis in five human NBs and NETs, also upon GDNF/TGF-β1 and retinoic acid (RA) treatment. According to our results, individual NBs and NETs reflected a certain stage of neural development characterized by their expression of discrete sets of regulatory genes.","abstract_html":"Induction of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) and pulmonary neuroendocrine tumors (NETs), which are neoplasms of neural origin, are molecularly different based on their expression of regulatory genes and that exposure to extrinsic factors will alter their growth potential. Using reverse-transcription polymerase chain reaction (RT-PCR) analysis, the present study compared the expression of about 50 regulatory genes that are expressed at early stages of neurogenesis in five human NBs and NETs, also upon GDNF/TGF-β1 and retinoic acid (RA) treatment. According to our results, individual NBs and NETs reflected a certain stage of neural development characterized by their expression of discrete sets of regulatory genes.","abstract_has_math":false,"creators":["Smit, Marithea"],"institution":"Department of Human Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Neuman, Toomas"],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002","date_published":"2002","updated_at":"2026-07-22T22:23:21Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3203","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Neuman, Toomas"]},{"key":"dc:creator","label":"Author","values":["Smit, Marithea"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-28T18:15:27Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-28T18:15:27Z"]},{"key":"dc:date.issued","label":"Date","values":["2002"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Human Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3203"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: leaves 139-178."]},{"key":"dc:description.abstract","label":"Abstract","values":["Induction of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) and pulmonary neuroendocrine tumors (NETs), which are neoplasms of neural origin, are molecularly different based on their expression of regulatory genes and that exposure to extrinsic factors will alter their growth potential. Using reverse-transcription polymerase chain reaction (RT-PCR) analysis, the present study compared the expression of about 50 regulatory genes that are expressed at early stages of neurogenesis in five human NBs and NETs, also upon GDNF/TGF-β1 and retinoic acid (RA) treatment. According to our results, individual NBs and NETs reflected a certain stage of neural development characterized by their expression of discrete sets of regulatory genes."]},{"key":"dc:title","label":"Title","values":["Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development"]}]}],"canonical_facts":{"dc:contributor.advisor":["Neuman, Toomas"],"dc:creator":["Smit, Marithea"],"dc:date.accessioned":["2014-07-28T18:15:27Z"],"dc:date.available":["2014-07-28T18:15:27Z"],"dc:date.issued":["2002"],"dc:description":["Bibliography: leaves 139-178."],"dc:description.abstract":["Induction of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) and pulmonary neuroendocrine tumors (NETs), which are neoplasms of neural origin, are molecularly different based on their expression of regulatory genes and that exposure to extrinsic factors will alter their growth potential. Using reverse-transcription polymerase chain reaction (RT-PCR) analysis, the present study compared the expression of about 50 regulatory genes that are expressed at early stages of neurogenesis in five human NBs and NETs, also upon GDNF/TGF-β1 and retinoic acid (RA) treatment. 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