{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/32033"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/32033","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"On the humoral mediation of the intestinal phase of gastric secretion","abstract":"The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected for some time, and recently the importance of this phase has been recognized. The intestinal phase is of particular interest in relation to the profound gastric hypersecretion associated with portacaval anastomosis. The results of many studies in dogs, and recently in man, have demonstrated conclusively that shunt-related gastric hyper-secretion is due to unmasking of the intestinal phase by hepatic bypass of a humoral stimulant that is normally inactivated by the liver. Definitive experiments have shown that this humoral agent is a hormone that arises in the jejunum. Elaboration of the hormone is triggered both by the entry of food into the jejunum and by a brief period of jejunal distension with a balloon.","abstract_html":"The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected for some time, and recently the importance of this phase has been recognized. The intestinal phase is of particular interest in relation to the profound gastric hypersecretion associated with portacaval anastomosis. The results of many studies in dogs, and recently in man, have demonstrated conclusively that shunt-related gastric hyper-secretion is due to unmasking of the intestinal phase by hepatic bypass of a humoral stimulant that is normally inactivated by the liver. Definitive experiments have shown that this humoral agent is a hormone that arises in the jejunum. Elaboration of the hormone is triggered both by the entry of food into the jejunum and by a brief period of jejunal distension with a balloon.","abstract_has_math":false,"creators":["Kester, Ralph Charles"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1973,"date_issued":"1973","date_published":"1973","updated_at":"2026-07-22T22:22:52Z","subjects":["Gastrointestinal Hormones"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/11427/32033","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Kester, Ralph Charles"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-06-04T08:17:19Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-06-04T08:17:19Z"]},{"key":"dc:date.issued","label":"Date","values":["1973"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Gastrointestinal Hormones"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/11427/32033"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected for some time, and recently the importance of this phase has been recognized. The intestinal phase is of particular interest in relation to the profound gastric hypersecretion associated with portacaval anastomosis. The results of many studies in dogs, and recently in man, have demonstrated conclusively that shunt-related gastric hyper-secretion is due to unmasking of the intestinal phase by hepatic bypass of a humoral stimulant that is normally inactivated by the liver. Definitive experiments have shown that this humoral agent is a hormone that arises in the jejunum. Elaboration of the hormone is triggered both by the entry of food into the jejunum and by a brief period of jejunal distension with a balloon."]},{"key":"dc:title","label":"Title","values":["On the humoral mediation of the intestinal phase of gastric secretion"]}]}],"canonical_facts":{"dc:creator":["Kester, Ralph Charles"],"dc:date.accessioned":["2020-06-04T08:17:19Z"],"dc:date.available":["2020-06-04T08:17:19Z"],"dc:date.issued":["1973"],"dc:description.abstract":["The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected for some time, and recently the importance of this phase has been recognized. The intestinal phase is of particular interest in relation to the profound gastric hypersecretion associated with portacaval anastomosis. The results of many studies in dogs, and recently in man, have demonstrated conclusively that shunt-related gastric hyper-secretion is due to unmasking of the intestinal phase by hepatic bypass of a humoral stimulant that is normally inactivated by the liver. Definitive experiments have shown that this humoral agent is a hormone that arises in the jejunum. Elaboration of the hormone is triggered both by the entry of food into the jejunum and by a brief period of jejunal distension with a balloon."],"dc:identifier.uri":["https://hdl.handle.net/11427/32033"],"dc:publisher.department":["Department of Medicine"],"dc:subject":["Gastrointestinal Hormones"],"dc:title":["On the humoral mediation of the intestinal phase of gastric secretion"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"]},"updated_at":"2026-07-22T22:22:52Z"}